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Study design: Adult male Japanese white rabbits (n=15, 12-16 weeks, 2.5-3kg) were used. The sinus lift was made from the nasal bone of a rabbit. Bone screws (Dual top auto-screw®) were implanted into the nasal bone, and after BIOPEX®-R was implanted into the left elevated space (operated side) an atelocollagen sponge (ACS: Teruplug®) was implanted into the right elevated space (control side). The rabbits were sacrificed at 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically. Results: Tight bonding without fibrous tissue continued between the bone screw and BIOPEX®-R, and the rigidity of the bone screw in the nasal bone was retained for 24 weeks in all cases. 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Use of self-setting α-tricalcium phosphate for maxillary sinus augmentation in rabbit
http://hdl.handle.net/2297/27799
http://hdl.handle.net/2297/277996673804f-a752-44d7-9dab-490c30f3b289
名前 / ファイル | ライセンス | アクション |
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ME-PR-UEKI-K-606.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Use of self-setting α-tricalcium phosphate for maxillary sinus augmentation in rabbit | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ueki, Koichiro
× Ueki, Koichiro× Okabe, Katsuhiko× Nakagawa, Kiyomasa× Yamamoto, Etsuhide |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Clinical Oral Implants Research 巻 22, 号 6, p. 606-612, 発行日 2011-06-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0905-7161 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1078090X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1600-0501.2010.02023.x | |||||
出版者 | ||||||
出版者 | Wiley-Blackwell | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The purpose of this study was to histologically and immuno-histochemically evaluate tissue changes in the maxillary sinus after bone screw implantation and maxillary sinus augmentation using self-setting α-tricalcium phosphate (α-TCP; BIOPEX®-R) in rabbit. Study design: Adult male Japanese white rabbits (n=15, 12-16 weeks, 2.5-3kg) were used. The sinus lift was made from the nasal bone of a rabbit. Bone screws (Dual top auto-screw®) were implanted into the nasal bone, and after BIOPEX®-R was implanted into the left elevated space (operated side) an atelocollagen sponge (ACS: Teruplug®) was implanted into the right elevated space (control side). The rabbits were sacrificed at 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically. Results: Tight bonding without fibrous tissue continued between the bone screw and BIOPEX®-R, and the rigidity of the bone screw in the nasal bone was retained for 24 weeks in all cases. The area ofnew bone formation increased gradually on both sides; however, there was no significant difference between both sides at 4, 12 and 24 weeks. The number of BMP-2-stained cells on the experimental side was significantly larger than that on the control side after 4 weeks (P=0.0361). Conclusion: This study suggested the usefulness of self-setting α-TCP (BIOPEX®-R) to maintain the rigidity of implanted bone screws from an early period, and the result of BMP-2 expression suggested that BIOPEX®-R could have bone-conductive activity in the maxillary sinus augmentation. © 2010 John Wiley & Sons A/S. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |