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Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish.
https://doi.org/10.24517/00014056
https://doi.org/10.24517/0001405697d0d259-ed6c-46bb-bbe7-afdaf1f80f22
名前 / ファイル | ライセンス | アクション |
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ME-PR-KATO-S-84.pdf (3.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00014056 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ogai, Kazuhiro
× Ogai, Kazuhiro× Nakatani, Kumi× Hisano, Suguru× Sugitani, Kayo× Koriyama, Yoshiki× Kato, Satoru |
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著者別表示 |
大貝, 和裕
× 大貝, 和裕× 杉谷, 加代× 郡山, 恵樹× 加藤, 聖 |
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書誌情報 |
Neuroscience Research 巻 88, p. 84-87, 発行日 2014-11-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0168-0102 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10641652 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neures.2014.07.010 | |||||
出版者 | ||||||
出版者 | Elsevier B.V. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesion (dpl) in ependymal cells, which was followed by cell proliferation. Sox2 knockdown significantly decreased the number of proliferating cells at 5 dpl. The results of this study suggest a role of Sox2 as one of the proliferation initiators in ependymal cells after SCI. © 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 12 months Embargo Period | |||||
権利 | ||||||
権利情報 | Copyright © Elsevier B.V. (CC-BY NC ND) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |