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TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex
http://hdl.handle.net/2297/43012
http://hdl.handle.net/2297/4301229c46364-e8c5-489a-b5e2-813254227adf
名前 / ファイル | ライセンス | アクション |
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ME-PR-MATSUMURA-M-e1004780.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Liang, Guoxin
× Liang, Guoxin× Liu, Guangyan× Kitamura, Kouichi× Wang, Zhe× Chowdhury, Sajeda× Md Monjurul, Ahasan× Wakae, Kousho× Koura, Miki× Shimadu, Miyuki× Kinoshita, Kazuo× Muramatsu, Masamichi |
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書誌情報 |
PLoS Pathogens 巻 11, 号 4, p. e1004780, 発行日 2015-04-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1553-7366 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.ppat.1004780 | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inhibition of viral replication. Immunoprecipitation reveals that AID physically associates with viral P protein that binds to specific virus RNA sequence called epsilon. AID also binds to an RNA degradation complex (RNA exosome proteins), indicating that AID, RNA exosome, and P protein form an RNP complex. Suppression of HBV transcripts by TGF-β was abrogated by depletion of either AID or RNA exosome components, suggesting that AID and the RNA exosome involve in TGF-β mediated suppression of HBV RNA. Moreover, AID-mediated HBV reduction does not occur when P protein is disrupted or when viral transcription is inhibited. These results suggest that induced expression of AID by TGF-β causes recruitment of the RNA exosome to viral RNP complex and the RNA exosome degrades HBV RNA in a transcription-coupled manner. © 2015 Liang et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004780 |