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Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report
http://hdl.handle.net/2297/41401
http://hdl.handle.net/2297/41401bbc8bd76-c2ed-42fa-9d70-94c654e0b4c2
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKANUMA-S-1119.pdf (535.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakanuma, Shinichi
× Nakanuma, Shinichi× Miyashita, Tomoharu× Hayashi, Hironori× Tajima, Hidehiro× Takamura, Hiroyuki× Tsukada, Tomoya× Okamoto, Koichi× Sakai, Seisho× Makino, Isamu× Kinoshita, Jun× Nakamura, Keishi× Oyama, Katsunobu× Inokuchi, Masafumi× Nakagawara, Hisatoshi× Ninomiya, Itasu× Kitagawa, Hirohisa× Fushida, Sachio× Fujimura, Takashi× Ohta, Tetsuo |
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書誌情報 |
Experimental and Therapeutic Medicine 巻 9, 号 4, p. 1119-1124, 発行日 2015-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1792-0981 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12610820 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/etm.2015.2245 | |||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is relatively rare subsequent to liver transplantation (LT). SOS refractory to medical therapy, however, can result in centrilobular fibrosis, portal hypertension and liver failure. Although sinusoidal endothelial cell damage around central venules (zone 3) occurs early in the development of SOS, the detailed mechanism of SOS development and its association with thrombocytopenia are not yet completely understood. The present report describes a patient who experienced SOS with unexplained thrombocytopenia following living donor LT. The progression of SOS resulted in graft dysfunction and the patient succumbed. The presence of platelets in the liver allograft was assayed immunohistochemically using antibody to the platelet marker cluster of differentiation 42b (platelet glycoprotein Ib). Platelet aggregates were found attached to hepatocytes along the sinusoid and within the cytoplasm of hepatocytes, particularly in zone 3. By contrast, no staining was observed in zone 1. These findings suggested that extravasated platelet aggregation in the space of Disse and the phagocytosis of platelets by hepatocytes were initiated by sinusoidal endothelial cell damage due to the toxicity of the immunosuppressant tacrolimus or a corticosteroid pulse, and that platelet activation and degranulation may be at least partially involved in the mechanism responsible for SOS. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |