WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "65b508d8-24a4-4bf8-9902-9a28481509d0"}, "_deposit": {"created_by": 3, "id": "14264", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14264"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014264", "sets": ["1134"]}, "author_link": ["24548", "24552", "24550", "24551", "24549", "24503", "24547", "24553"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "463", "bibliographicPageStart": "455", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "Experimental Animals"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本実験動物学会 = Japanese Association for Laboratory Animal Science"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1538/expanim.16-0043", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jalas.jp/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/browse/expanim", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2016 Japanese Association for Laboratory Animal Science 日本実験動物学会"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11032321", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1341-1357", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mori, Taiki"}], "nameIdentifiers": [{"nameIdentifier": "24547", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murasawa, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "24548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikai, Rina"}], "nameIdentifiers": [{"nameIdentifier": "24549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayakawa, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "24550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "24503", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30542253", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30542253"}, {"nameIdentifier": "30542253", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030542253"}]}, {"creatorNames": [{"creatorName": "Ogiso, Noboru"}], "nameIdentifiers": [{"nameIdentifier": "24551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niida, Shumpei"}], "nameIdentifiers": [{"nameIdentifier": "24552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Ken"}], "nameIdentifiers": [{"nameIdentifier": "24553", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-NAKAMURA-H-455.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "ME-PR-NAKAMURA-H-455.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14264/files/ME-PR-NAKAMURA-H-455.pdf"}, "version_id": "3b4f2b2f-afba-4f80-8112-98238c85bff5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "conditional transgenic mouse", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cre-loxP system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-6", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Generation of a transgenic mouse line for conditional expression of human IL-6", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Generation of a transgenic mouse line for conditional expression of human IL-6"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/46746", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "14264", "relation": {}, "relation_version_is_last": true, "title": ["Generation of a transgenic mouse line for conditional expression of human IL-6"], "weko_shared_id": -1}
Generation of a transgenic mouse line for conditional expression of human IL-6
http://hdl.handle.net/2297/46746
http://hdl.handle.net/2297/46746e86e362e-6577-41da-bf8f-3cc3fff8a310
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-NAKAMURA-H-455.pdf (1.8 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Generation of a transgenic mouse line for conditional expression of human IL-6 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mori, Taiki
× Mori, Taiki× Murasawa, Yusuke× Ikai, Rina× Hayakawa, Tomoko× Nakamura, Hiroyuki× Ogiso, Noboru× Niida, Shumpei× Watanabe, Ken |
|||||
書誌情報 |
Experimental Animals 巻 65, 号 4, p. 455-463, 発行日 2016-01-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341-1357 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11032321 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1538/expanim.16-0043 | |||||
出版者 | ||||||
出版者 | 日本実験動物学会 = Japanese Association for Laboratory Animal Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers. | |||||
権利 | ||||||
権利情報 | Copyright © 2016 Japanese Association for Laboratory Animal Science 日本実験動物学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jalas.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/expanim |