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ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function
http://hdl.handle.net/2297/20469
http://hdl.handle.net/2297/20469bd0d67c6-5aa8-48f8-8b88-fab1c55b4df6
名前 / ファイル | ライセンス | アクション |
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ME-PR-WADA-T-1345.pdf (5.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shindo, Takayuki
× Shindo, Takayuki× Kurihara, Hiroki× Kuno, Kouji× Yokoyama, Hitoshi× Wada, Takashi× Kurihara, Yukiko× Imai, Tomihiko× Wang, Yuhui× Ogata, Masafumi× Nishimatsu, Hiroaki× Moriyama, Nobuo× Oh-hashi, Yoshio× Morita, Hiroyuki× Ishikawa, Takatoshi× Nagai, Ryozo× Yazaki, Yoshio× Matsushima, Kouji |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Journal of Clinical Investigation 巻 105, 号 10, p. 1345-1352, 発行日 2000-05-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9738 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1172/JCI8635 | |||||
出版者 | ||||||
出版者 | American Society for Clinical Investigation | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon adenocarcinoma, is unusual in that it contains thrombospondin type I motifs and anchors to the extracellular matrix. To elucidate the biological role of ADAMTS-1, we developed ADAMTS-1-null mice by gene targeting. Targeted disruption of the mouse ADAMTS-1 gene resulted in growth retardation with adipose tissue malformation. Impaired female fertilization accompanied by histological changes in the uterus and ovaries also resulted. Furthermore, ADAMTS-1(-/-) mice demonstrated enlarged renal calices with fibrotic changes from the ureteropelvic junction through the ureter, and abnormal adrenal medullary architecture without capillary formation. ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function. Moreover, the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jci.org/articles/view/8635 |