WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "0fc543a4-003e-41c8-ac7c-ba25dfd3ff05"}, "_deposit": {"created_by": 3, "id": "15258", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "15258"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00015258", "sets": ["1135"]}, "author_link": ["66", "35", "27588", "27590", "27589", "27591", "171", "27592"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-10-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "850", "bibliographicPageStart": "845", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{"bibliographic_title": "Journal of Health Science = 衛生化学"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2. ©2009 The Pharmaceutical Society of Japan.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Pharmaceutical Society of Japan = 日本薬学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/jhs.55.845", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.pharm.or.jp/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://japanlinkcenter.org/JST.JSTAGE/jhs/55.845", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2009 by The Pharmaceutical Society of Japan"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11316464", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1344-9702", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Motoyama, Yumi"}], "nameIdentifiers": [{"nameIdentifier": "27588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bekki, Kanae"}], "nameIdentifiers": [{"nameIdentifier": "27589", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chung, Sang Woon"}], "nameIdentifiers": [{"nameIdentifier": "27590", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tang, Ning"}], "nameIdentifiers": [{"nameIdentifier": "27591", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kameda, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "171", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50398426", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50398426"}, {"nameIdentifier": "50398426", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050398426"}]}, {"creatorNames": [{"creatorName": "Toriba, Akira"}], "nameIdentifiers": [{"nameIdentifier": "66", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50313680", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50313680"}, {"nameIdentifier": "50313680", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50313680"}, {"nameIdentifier": "50313680", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050313680"}]}, {"creatorNames": [{"creatorName": "Taguchi, Keiko"}], "nameIdentifiers": [{"nameIdentifier": "27592", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayakawa, Kazuichi"}], "nameIdentifiers": [{"nameIdentifier": "35", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40115267", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40115267"}, {"nameIdentifier": "40115267", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40115267"}, {"nameIdentifier": "40115267", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040115267"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-HAYAKAWA-K-845.pdf", "filesize": [{"value": "394.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 394800.0, "url": {"label": "PH-PR-HAYAKAWA-K-845.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/15258/files/PH-PR-HAYAKAWA-K-845.pdf"}, "version_id": "6343d84e-fa38-4df2-b5cd-064cf5db08f5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cytotoxicity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hydrogen peroxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ortho-quinoid polycyclic aromatic hydrocarbon", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Redox cycle", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": "http://hdl.handle.net/2297/29012", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-04"}, "publish_date": "2017-10-04", "publish_status": "0", "recid": "15258", "relation": {}, "relation_version_is_last": true, "title": ["Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells"], "weko_shared_id": -1}
Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
http://hdl.handle.net/2297/29012
http://hdl.handle.net/2297/2901201236fc9-87fd-4473-8c7a-ac15062c28fd
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-HAYAKAWA-K-845.pdf (394.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Motoyama, Yumi
× Motoyama, Yumi× Bekki, Kanae× Chung, Sang Woon× Tang, Ning× Kameda, Takayuki× Toriba, Akira× Taguchi, Keiko× Hayakawa, Kazuichi |
|||||
書誌情報 |
Journal of Health Science = 衛生化学 巻 55, 号 5, p. 845-850, 発行日 2009-10-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1344-9702 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316464 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/jhs.55.845 | |||||
出版者 | ||||||
出版者 | Pharmaceutical Society of Japan = 日本薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2. ©2009 The Pharmaceutical Society of Japan. | |||||
権利 | ||||||
権利情報 | Copyright (c) 2009 by The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.pharm.or.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.JSTAGE/jhs/55.845 |