WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "dde95e34-4395-49e5-a529-db4e804d707d"}, "_deposit": {"created_by": 3, "id": "26603", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "26603"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00026603", "sets": ["1763"]}, "author_link": ["342", "438", "389", "20266", "44630", "539", "333"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-08-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "845", "bibliographicPageStart": "840", "bibliographicVolumeNumber": "86", "bibliographic_titles": [{"bibliographic_title": "American Journal of Cardiology"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by primary hypercholesterolemia and premature coronary artery disease (CAD). However, the development of CAD in FH shows considerable interindividual variations. Elevated levels of plasma homocysteine have been recognized as independent risk factors for CAD. A 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutation (valine [V] was substituted for alanine [A]) has been reported to be associated with elevated levels of plasma homocysteine in mutant homozygotes (i.e., VV). We studied 199 consecutive male heterozygous FH patients, 99 with and 100 without CAD. In the CAD group, genotype VV and V alleles were significantly more frequent than in the non-CAD group (15% vs 7% in genotypes [p = 0.035] and 0.41 vs 0.30 in alleles [p = 0.017]). The mean ages at onset in the CAD group were 50, 51, and 43 years for genotypes AA, AV, and VV, respectively (p \u003c0.05); the age of onset of CAD in genotype VV was significantly lower than in the other 2 genotypes. Kaplan-Meier survivor curves indicated that the development of CAD was significantly accelerated by MTHFR mutation, probably in a gene dose-dependent manner. Furthermore, only MTHFR genotype VV was shown to be an independent predictor of the early onset of CAD in a stepwise multiple regression analysis. The mean plasma homocysteine levels of genotype VV were significantly higher than those of the other 2 genotypes. Thus, the MTHFR mutation appears to accelerate the onset of CAD through elevation of plasma homocysteine levels in male heterozygous patients with FH.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/S0002-9149(00)01103-6", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0002-9149", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawashiri, Masaaki"}, {"creatorName": "川尻, 剛照"}], "nameIdentifiers": [{"nameIdentifier": "333", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090345637"}]}, {"creatorNames": [{"creatorName": "Kajinami, Kouji"}], "nameIdentifiers": [{"nameIdentifier": "44630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nohara, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "342", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050313648"}]}, {"creatorNames": [{"creatorName": "Yagi, Kunimasa"}], "nameIdentifiers": [{"nameIdentifier": "438", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30293343", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30293343"}, {"nameIdentifier": "30293343", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30293343"}, {"nameIdentifier": "30293343", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030293343"}]}, {"creatorNames": [{"creatorName": "Inazu, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "539", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080293348"}]}, {"creatorNames": [{"creatorName": "Koizumi, Junji"}], "nameIdentifiers": [{"nameIdentifier": "20266", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20161846", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20161846"}, {"nameIdentifier": "20161846", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020161846"}]}, {"creatorNames": [{"creatorName": "Mabuchi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "389", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00019960"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000019960"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HO-PR-KAWASHIRI-M-manuscript.pdf", "filesize": [{"value": "194.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 194300.0, "url": {"label": "HO-PR-KAWASHIRI-M-manuscript.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/26603/files/HO-PR-KAWASHIRI-M-manuscript.pdf"}, "version_id": "bf6aacbf-c6a3-4a7f-a8c7-e53d96c31afd"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "http://hdl.handle.net/2297/1767", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "26603", "relation": {}, "relation_version_is_last": true, "title": ["Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia"], "weko_shared_id": 3}
Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia
http://hdl.handle.net/2297/1767
http://hdl.handle.net/2297/1767f2a2e7ed-45d8-4f99-a26b-3f090fc8679d
名前 / ファイル | ライセンス | アクション |
---|---|---|
HO-PR-KAWASHIRI-M-manuscript.pdf (194.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||
---|---|---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||||
タイトル | ||||||||
タイトル | Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Kawashiri, Masaaki
× Kawashiri, Masaaki
WEKO
333
× Kajinami, Kouji× Nohara, Atsushi× Yagi, Kunimasa× Inazu, Akihiro× Koizumi, Junji× Mabuchi, Hiroshi |
|||||||
書誌情報 |
American Journal of Cardiology 巻 86, 号 8, p. 840-845, 発行日 2000-08-01 |
|||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0002-9149 | |||||||
DOI | ||||||||
関連タイプ | isVersionOf | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | https://doi.org/10.1016/S0002-9149(00)01103-6 | |||||||
出版者 | ||||||||
出版者 | Elsevier | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by primary hypercholesterolemia and premature coronary artery disease (CAD). However, the development of CAD in FH shows considerable interindividual variations. Elevated levels of plasma homocysteine have been recognized as independent risk factors for CAD. A 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutation (valine [V] was substituted for alanine [A]) has been reported to be associated with elevated levels of plasma homocysteine in mutant homozygotes (i.e., VV). We studied 199 consecutive male heterozygous FH patients, 99 with and 100 without CAD. In the CAD group, genotype VV and V alleles were significantly more frequent than in the non-CAD group (15% vs 7% in genotypes [p = 0.035] and 0.41 vs 0.30 in alleles [p = 0.017]). The mean ages at onset in the CAD group were 50, 51, and 43 years for genotypes AA, AV, and VV, respectively (p <0.05); the age of onset of CAD in genotype VV was significantly lower than in the other 2 genotypes. Kaplan-Meier survivor curves indicated that the development of CAD was significantly accelerated by MTHFR mutation, probably in a gene dose-dependent manner. Furthermore, only MTHFR genotype VV was shown to be an independent predictor of the early onset of CAD in a stepwise multiple regression analysis. The mean plasma homocysteine levels of genotype VV were significantly higher than those of the other 2 genotypes. Thus, the MTHFR mutation appears to accelerate the onset of CAD through elevation of plasma homocysteine levels in male heterozygous patients with FH. | |||||||
著者版フラグ | ||||||||
出版タイプ | AM | |||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |