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Characterization of a rare IL-10–competent B-cell subset in humans that parallels mouse regulatory B10 cells
http://hdl.handle.net/2297/45180
http://hdl.handle.net/2297/45180dde1c3da-9431-4f7a-b6d8-d6d876ab5a0c
名前 / ファイル | ライセンス | アクション |
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HO-PR-MATSUSHITA-T-530.pdf (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Characterization of a rare IL-10–competent B-cell subset in humans that parallels mouse regulatory B10 cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Iwata, Yohei
× Iwata, Yohei× Matsushita, Takashi× Horikawa, Mayuka× DiLillo, David J.× Yanaba, Koichi× Venturi, Guglielmo M.× Szabolcs, Paul M.× Bernstein, Steven H.× Magro, Cynthia M.× Williams, Armistead D.× Hall, Russell P.× Clair, E. William St.× Tedder, Thomas F. |
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書誌情報 |
Blood 巻 117, 号 2, p. 530-541, 発行日 2011-01-17 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-4971 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00567156 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1182/blood-2010-07-294249 | |||||
出版者 | ||||||
出版者 | American Society of Hematology | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Regulatory B cells control inflammation and autoimmunity in mice, including the recently identified IL-10-competent B10 cell subset that represents 1% to 3% of spleen B cells. In this study, a comparable IL-10-competent B10 cell subset was characterized in human blood. B10 cells were functionally identified by their ability to express cytoplasmic IL-10 after 5 hours of ex vivo stimulation, whereas progenitor B10 (B10pro) cells required 48 hours of in vitro stimulation before they acquired the ability to express IL-10. B10 and B10pro cells represented 0.6% and approximately 5% of blood B cells, respectively. Ex vivo B10 and B10pro cells were predominantly found within the CD24 hiCD27+ B-cell subpopulation that was able to negatively regulate monocyte cytokine production through IL-10-dependent pathways during in vitro functional assays. Blood B10 cells were present in 91 patients with rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren syndrome, autoimmune vesiculobullous skin disease, or multiple sclerosis, and were expanded in some cases as occurs in mice with autoimmune disease. Mean B10 + B10pro-cell frequencies were also significantly higher in patients with autoimmune disease compared with healthy controls. The characterization of human B10 cells will facilitate their identification and the study of their regulatory activities during human disease. © 2011 by The American Society of Hematology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |