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オウゴンの心・血管系に対する作用 : baicalin の血管平滑筋収縮作用とその作用機序
http://hdl.handle.net/2297/23601
http://hdl.handle.net/2297/23601eb4c02d6-0eb2-41a4-aa81-9c8dde432f56
名前 / ファイル | ライセンス | アクション |
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PH-PR-MIAMOTO-K-238.pdf (734.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | オウゴンの心・血管系に対する作用 : baicalin の血管平滑筋収縮作用とその作用機序 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of Scutellariae Radix on the cardiovascular system : Vasoconstrictile effect of baicalin and its mechanism of action | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
脇田, 広美
× 脇田, 広美× 鈴木, 永雄× 宮本, 謙一 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院薬剤部 | |||||
書誌情報 |
Journal of traditional medicines = 和漢医薬学雑誌 巻 19, 号 6, p. 238-245, 発行日 2002-12-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-1447 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
出版者 | ||||||
出版者 | Medical and Pharmaceutical Society for WAKAN-YAKU = 和漢医薬学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Scutellariae Radix and its main constituent, baicalin, concentration-dependently contracted the isolated rat aorta, and its contractile responses were tachyphylaxic. Wogonin, another constituent in Scutellariae Radix, conversely concentration-dependently relaxed the contraction induced by phenylephrine in the isolated rat aorta, and the relaxation was not tachyphylaxic. Applying the sample containing baicalin and wogonin in the same proportion as the content ratio in Scutellariae Radix, it was observed that the isolate rat aorta contracted in the same way as Scutellariae Radix and baicalin. From the results with adrenergic blockers, serotonergic blockers, tetrodotoxine and NO synthase inhibitors, it is suggested that the mechanism of contractile effect of Scutellariae Radix and baicalin on the vascular smooth muscle is not based on the adrenergic and serotonergic system, and endothelium derived relaxing factor. Furthermore, cyclooxygenase inhibitors suppressed the contractile response to baicalin in the isolated rat aorta, correlation was identified between prostanoids concentration and the contraction by baicalin. Repeated applications of baicalin induced the decrease of prostanoids production while weakening the strength of contraction. The above results suggest that prostanoids production is involved in the contractile response to baicalin. | |||||
権利 | ||||||
権利情報 | 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.wakan-iyaku.gr.jp/index2.html | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110001846577/en/ |