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CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports
http://hdl.handle.net/2297/19435
http://hdl.handle.net/2297/19435a5660cb3-9bf8-49af-9d77-8afd3d9b29b1
名前 / ファイル | ライセンス | アクション |
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ME-PR-IKEDA-T-62.pdf (289.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Tokuhei
× Ikeda, Tokuhei× Noto, Daisuke× Noguchi-Shinohara, Moeko× Ono, Kenjiro× Takahashi, Kazuya× Ishida, Chiho× Yoshita, Mitsuhiro× Kawaguchi, Masahito× Kawahara, Norio× Iwasa, Kazuo× Tomita, Katsuro× Yamada, Masahito |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院神経内科 | |||||
書誌情報 |
Clinical Neurology and Neurosurgery 巻 112, 号 1, p. 62-64, 発行日 2010-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0303-8467 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00607851 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.clineuro.2009.08.020 | |||||
出版者 | ||||||
出版者 | Elsevier BV | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report two cases of superficial siderosis (SS) of the central nervous system (CNS), which is caused by chronic haemorrhaging into the subarachnoid space with haemosiderin deposition in the superficial portion of the CNS. Patient 1 had fluid collection in the spinal canal, which was reported as the source of the chronic bleeding. Patient 2 was bleeding from thickened dura at the level of the sacral vertebrae. Both of the patients had xanthochromic cerebrospinal fluid. We surgically repaired the sources of bleeding. Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms were not aggravated for about 1 year. We measured several CSF markers of SS before and after surgery. Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-tau), iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly elevated at diagnosis. After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly reduced while CSF-iron and CSF-ferritin had not decreased. It is suggested that CSF-t-tau and CSF-p-tau reflected the neural damage in SS and were useful to evaluate the effectiveness of SS therapies. © 2009 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/03038467 |