WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "5988b2d6-c957-476a-adbd-debf6965476b"}, "_deposit": {"created_by": 3, "id": "27405", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "27405"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00027405", "sets": ["1779"]}, "author_link": ["47623", "47624", "17028", "47625", "62", "457", "108", "49"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-04-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "15", "bibliographicPageEnd": "2237", "bibliographicPageStart": "2228", "bibliographicVolumeNumber": "29", "bibliographic_titles": [{"bibliographic_title": "Oncogene"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Pim-3, a proto-oncogene with serine/threonine kinase activity, was enhanced in hepatocellular carcinoma (HCC) tissues. To address the roles of Pim-3 in HCC development, we prepared transgenic mice that express human Pim-3 selectively in liver. The mice were born at a Mendelian ratio, were fertile and did not exhibit any apparent pathological changes in the liver until 1 year after birth. Pim-3-transgenic mouse-derived hepatocytes exhibited accelerated cell cycle progression. The administration of a potent hepatocarcinogen, diethylnitrosamine (DEN), induced accelerated proliferation of liver cells in Pim-3 transgenic mice in the early phase, compared with that observed for wild-type mice. Treatment with DEN induced lipid droplet accumulation with increased proliferating cell numbers 6 months after the treatment. Eventually, wild-type mice developed HCC with a frequency of 40% until 10 month after the treatment. Lipid accumulation was accelerated in Pim-3 transgenic mice with higher proliferating cell numbers, compared with that observed for wild-type mice. Pim-3 transgenic mice developed HCC with a higher incidence (80%) and a heavier burden, together with enhanced intratumoral CD31-positive vascular areas, compared with that observed for wild-type mice. These observations indicate that Pim-3 alone cannot cause, but can accelerate HCC development when induced by a hepatocarcinogen, such as DEN. © 2010 Macmillan Publishers Limited. All rights reserved.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学がん研究所", "subitem_description_type": "Other"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/onc.2009.504", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10687380", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0950-9232", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Wu, Yu"}], "nameIdentifiers": [{"nameIdentifier": "47623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Ying Ying"}], "nameIdentifiers": [{"nameIdentifier": "47624", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamoto, Yasunari"}], "nameIdentifiers": [{"nameIdentifier": "108", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40293352", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40293352"}, {"nameIdentifier": "40293352", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040293352"}]}, {"creatorNames": [{"creatorName": "Li, Ying-Yi"}], "nameIdentifiers": [{"nameIdentifier": "47625", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Baba, Tomohisa"}], "nameIdentifiers": [{"nameIdentifier": "457", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00452095", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00452095"}, {"nameIdentifier": "00452095", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00452095"}, {"nameIdentifier": "00452095", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000452095"}]}, {"creatorNames": [{"creatorName": "Kaneko, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "62", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60185923"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60185923"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060185923"}]}, {"creatorNames": [{"creatorName": "Fujii, Chifumi"}], "nameIdentifiers": [{"nameIdentifier": "17028", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10361982", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010361982"}]}, {"creatorNames": [{"creatorName": "Mukaida, Naofumi"}], "nameIdentifiers": [{"nameIdentifier": "49", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30182067", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30182067"}, {"nameIdentifier": "30182067", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30182067"}, {"nameIdentifier": "30182067", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030182067"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-MUKAIDA-N-2228.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "CA-PR-MUKAIDA-N-2228.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/27405/files/CA-PR-MUKAIDA-N-2228.pdf"}, "version_id": "ddeb42c4-bef8-45de-9d42-20710c06ecac"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bad", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell cycle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Serine/threonine kinase", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver"}]}, "item_type_id": "4", "owner": "3", "path": ["1779"], "permalink_uri": "http://hdl.handle.net/2297/24282", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "27405", "relation": {}, "relation_version_is_last": true, "title": ["Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver"], "weko_shared_id": -1}
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver
http://hdl.handle.net/2297/24282
http://hdl.handle.net/2297/24282fb5d3149-6f61-4f7f-949c-39cc032363ad
名前 / ファイル | ライセンス | アクション |
---|---|---|
CA-PR-MUKAIDA-N-2228.pdf (1.3 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wu, Yu
× Wu, Yu× Wang, Ying Ying× Nakamoto, Yasunari× Li, Ying-Yi× Baba, Tomohisa× Kaneko, Shuichi× Fujii, Chifumi× Mukaida, Naofumi |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん研究所 | |||||
書誌情報 |
Oncogene 巻 29, 号 15, p. 2228-2237, 発行日 2010-04-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0950-9232 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10687380 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/onc.2009.504 | |||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Pim-3, a proto-oncogene with serine/threonine kinase activity, was enhanced in hepatocellular carcinoma (HCC) tissues. To address the roles of Pim-3 in HCC development, we prepared transgenic mice that express human Pim-3 selectively in liver. The mice were born at a Mendelian ratio, were fertile and did not exhibit any apparent pathological changes in the liver until 1 year after birth. Pim-3-transgenic mouse-derived hepatocytes exhibited accelerated cell cycle progression. The administration of a potent hepatocarcinogen, diethylnitrosamine (DEN), induced accelerated proliferation of liver cells in Pim-3 transgenic mice in the early phase, compared with that observed for wild-type mice. Treatment with DEN induced lipid droplet accumulation with increased proliferating cell numbers 6 months after the treatment. Eventually, wild-type mice developed HCC with a frequency of 40% until 10 month after the treatment. Lipid accumulation was accelerated in Pim-3 transgenic mice with higher proliferating cell numbers, compared with that observed for wild-type mice. Pim-3 transgenic mice developed HCC with a higher incidence (80%) and a heavier burden, together with enhanced intratumoral CD31-positive vascular areas, compared with that observed for wild-type mice. These observations indicate that Pim-3 alone cannot cause, but can accelerate HCC development when induced by a hepatocarcinogen, such as DEN. © 2010 Macmillan Publishers Limited. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |