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Regulatory interaction between NBS1 and DNMT1 responding to DNA damage
http://hdl.handle.net/2297/36516
http://hdl.handle.net/2297/36516496b3036-1e21-4fca-862f-a0432696f6aa
名前 / ファイル | ライセンス | アクション |
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CA-PR-HAYASHI-N-429.pdf (713.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Regulatory interaction between NBS1 and DNMT1 responding to DNA damage | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hayashi, Naoyuki
× Hayashi, Naoyuki× Kobayashi, Masahiko× Shamma, Awad× Morimura, Yoko× Takahashi, Chiaki× Yamamoto, Ken-ichi |
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書誌情報 |
Journal of Biochemistry 巻 145, 号 4, p. 429-435, 発行日 2013-11-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-924X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694073 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jb/mvt071 | |||||
出版者 | ||||||
出版者 | Japanese Biochemical Society 日本生化学会 / Oxford University Press (OUP) | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | NBS1 is the causative gene product of Nijmegen breakage syndrome (NBS), a recessive genetic disorder resulting in chromosomal instability and immunodeficiency. We isolated DNMT1 cDNA by two-hybrid screening by using NBS1 as bait to study its function in DNA replication and damage checkpoint. DNMT1 encodes DNA methyltransferase 1, which maintains the genomic methylation pattern and also regulates the checkpoint pathway via interactions with various factors, such as CHK1, p53, Rb and ATM. The interaction between NBS1 and DNMT1 was observed under conditions of hydroxyl urea treatment, resulting in replication stall and mitomycin C treatment resulting in DNA damage. Additionally, we mapped their binding regions to the N-terminus of NBS1 (including the forkhead- associated domain) and amino acids 14011503 in the target recognition domain in the C-terminus of DNMT1. Under DNA replication stall conditions, DNMT1 was recruited to the survivin promoter by p53, and it repressed survivin expression via hetrochromatin formation; this regulation was dependent on the NBS1 genotype. These results suggest that DNMT1 function in the regulatory response is controlled by NBS1. © The Authors 2013. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jbsoc.or.jp/ |