WEKO3
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Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity
https://doi.org/10.24517/00027436
https://doi.org/10.24517/00027436f9c25d65-2256-4460-9f76-c70b9e002485
名前 / ファイル | ライセンス | アクション |
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CA-PR-MUKAIDA-N-107.pdf (746.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00027436 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Wang, Ying-Ying
× Wang, Ying-Ying× Taniguchi, Tsuyoshi× Baba, Tomohisa× Li, Ying-Yi× Ishibashi, Hiroyuki× Mukaida, Naofumi |
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著者別表示 |
谷口, 剛史
× 谷口, 剛史× 馬場, 智久× 石橋, 弘行× 向田, 直史 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学がん進展制御研究所 | |||||
書誌情報 |
Cancer Science 巻 103, 号 1, p. 107-115, 発行日 2012-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-9032 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11808050 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1349-7006.2011.02117.x | |||||
出版者 | ||||||
出版者 | Japanese Cancer Association = 日本癌学会 / Wiley-Blackwell | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in malignant lesions, but not in normal tissues, of endoderm-derived organs, including the pancreas, liver, colon, and stomach. Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinogen. These observations suggest that a chemical targeting Pim-3 kinase may be a novel type of anticancer drug. In the present study, we screened low molecular weight chemicals and observed that the phenanthrene derivative T26 potently inhibited Pim-3 and Pim-1, but only weakly inhibited Pim-2. Moreover, T26 markedly inhibited the in vitro growth of human pancreatic cancer cell lines by inducing apoptosis and G 2/M arrest. The growth inhibitory effects of T26 were reversed by overexpression of Pim-3 cDNA in human pancreatic cancer cells, indicating that T26 acts primarily on Pim-3. Furthermore, T26 inhibited the growth of a human pancreatic cancer cell line in nude mice without causing apparent adverse effects when it was administered after tumor formation was evident. These observations imply that the chemical and its related compounds may be effective for the treatment of cancers in which there is aberrant Pim-3 expression. © 2011 Japanese Cancer Association. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |