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Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway
http://hdl.handle.net/2297/40597
http://hdl.handle.net/2297/40597f38a5e99-1052-4b90-98e5-30c73adcc3fb
名前 / ファイル | ライセンス | アクション |
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CA-PR-TAKINO-T-251.pdf (650.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshimoto, Taisuke
× Yoshimoto, Taisuke× Takino, Takahisa× Li, Zichen× Domoto, Takahiro× Sato, Hiroshi |
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書誌情報 |
Biochemical and Biophysical Research Communications 巻 455, 号 3-4, p. 251-255, 発行日 2014-12-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2014.10.154 | |||||
出版者 | ||||||
出版者 | Academic Press / Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells. Knockdown of vinculin induced phenotypical change by reducing cell-cell and cell-extracellular matrix adhesions, and enhanced MT1-MMP expression at transcription level and subsequent cell migration. Up-regulation of MT1-MMP transcription by vinculin knockdown was abrogated by ERK inhibition. These results suggest that vinculin negatively regulates malignant phenotype of tumor cells including MT1-MMP transcription through MEK/ERK pathway. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |