Biochemical and Biophysical Research Communications
巻
455
号
3-4
ページ
251 - 255
発行年
2014-12-12
ISSN
0006-291X
NCID
AA00564395
DOI
10.1016/j.bbrc.2014.10.154
出版者
Academic Press / Elsevier
抄録
Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells. Knockdown of vinculin induced phenotypical change by reducing cell-cell and cell-extracellular matrix adhesions, and enhanced MT1-MMP expression at transcription level and subsequent cell migration. Up-regulation of MT1-MMP transcription by vinculin knockdown was abrogated by ERK inhibition. These results suggest that vinculin negatively regulates malignant phenotype of tumor cells including MT1-MMP transcription through MEK/ERK pathway.
Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway
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