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Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis
http://hdl.handle.net/2297/9510
http://hdl.handle.net/2297/951011aee3b2-f923-4f67-a225-c7282411755d
名前 / ファイル | ライセンス | アクション |
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HS-PR-YOSHIKAWA-H-2007.pdf (411.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Furukawa, Yutaka
× Furukawa, Yutaka× Yoshikawa, Hiroaki× Iwasa, Kazuo× Yamada, Masahito |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学保健管理センター | |||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 115 | |||||
書誌情報 |
Journal of Neuroimmunology 巻 195, 号 1-2, p. 108-115, 発行日 2008-03-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0165-5728 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1045958X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jneuroim.2007.12.008 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To clarify the long-term efficacy, safety and the cytokine network-modulating effects of tacrolimus in myasthenia gravis, medical records of 86 newly diagnosed consecutive patients and nine steroid-dependent patients were retrospectively reviewed, and peripheral blood mononuclear cells (PBMC) were cultured for the cytokine profile. Steroid reduction effects were observed by using tacrolimus, and no serious adverse effects were observed. The culture study showed reduced IL-12, IL-17, IFN-γ, GM-CSF, TNF-α and MIP-1β, and elevated IL-10 in the PBMC from patients who received tacrolimus, which suggests inhibition of T cells and macrophages, and enhancement of type 1 regulatory T cells. © 2008 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |