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胆管癌、膵癌にみられるIgG4 組織反応は癌の免疫抑制を反映している
https://doi.org/10.24517/00034498
https://doi.org/10.24517/00034498ea02b22d-0609-4402-88f7-98cf50efd011
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKANUMA-Y-kaken 2014-4p.pdf (121.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 胆管癌、膵癌にみられるIgG4 組織反応は癌の免疫抑制を反映している | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | IgG4 reaction in cholangiocarcinoma and pancreatic carcinoma reflects an evasion from host immunosurvilance by carcinoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034498 | |||||
ID登録タイプ | JaLC | |||||
著者 |
中沼, 安二
× 中沼, 安二 |
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著者別表示 |
Nakanuma, Yasuni
× Nakanuma, Yasuni |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2013 Fiscal Year Final Research Report 巻 2012-04-01 – 2014-03-31, p. 4p., 発行日 2014-06-09 |
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出版者 | ||||||
出版者 | 金沢大学医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 胆管癌の外科切除材料を収集し、胆管癌およびその前癌病変であるbiliary intraepithelial neoplasm (BilIIN)を中心に、癌化に伴うIgG4組織反応およびその発生機序を検討した。胆道癌においてはIgG4陽性形質細胞浸潤を伴う症例が存在し、IgG4組織反応はTreg細胞等を介した腫瘍免疫回避機構を反映すること、また、癌細胞自身がTreg細胞類似の免疫抑制機序を有し、IgG4組織反応に関与している可能性が示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The relation between cholangiocarcinoma and its precursor lesion (BilIN) and IgG4-related tissue reaction with respect to carcinogenesis was examined. About 30% of cholangiocarcinoma and BilIN showed infiltration of considerable number of IgG4+ plasma cells. There is correlation between expression of Fox3 and IgG4 tissue reaction. Clinicopathological study showed that the cholangiocarcinoma patients with IgG4 tissue reaction showed poor biological behaviors and poor post-operative survival. Cell culture studies showed that cultured cholangiocarcinoma cells express Fox3 mRNA and IL10 mRNA, and cancer cells present immunoregulatory roles by expressing these molecules. It seems plausible that cancer cells themselves are involved in IgG4 tissue reaction. In conclusion, some cholangiocarcinoma showed rich IgG4+ plasma cells and IgG4 tissue reaction reflect an evasion from immunosurveillance of host and cancer cells themsevels are involved in IgG4 tissue reaction by playing roles of Tregs. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24659160, 研究期間(年度):2012-04-01 – 2014-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「胆管癌、膵癌にみられるIgG4 組織反応は癌の免疫抑制を反映している」課題番号24659160 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659160/24659160seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10115256 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10115256 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659160/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659160/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659160/24659160seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659160/24659160seika/ |