WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "18b7a0a9-89cd-4d08-b852-f7fb07d14f76"}, "_deposit": {"created_by": 3, "id": "34519", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "34519"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00034519", "sets": ["2820"]}, "author_link": ["84772", "124"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-05-29", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "5p.", "bibliographicVolumeNumber": "2011-2013", "bibliographic_titles": [{"bibliographic_title": "平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"}, {"bibliographic_title": "2013 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takino, Takahisa"}], "nameIdentifiers": [{"nameIdentifier": "84772", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40322119", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40322119"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "MT1-MMPを発現抑制したHT1080細胞とRat1線維芽細胞の共培養では、FN繊維がRat1からHT1080細胞の細胞接着斑に伸展し、N-カドヘリン接着が形成された。また、N-カドヘリン阻害は、MT1-MMPを発現抑制したHT1080細胞におけるFN matrix形成を抑制した。以上の結果から、MT1-MMPは細胞接着斑上における初期のFNの重合を抑制することによりN-カドヘリン接着の安定化とFN matrix形成を阻害し、結果的に腫瘍細胞の細胞運動と増殖を誘導することが示唆された。", "subitem_description_type": "Abstract"}, {"subitem_description": "We have shown that membrane-type 1 matrix metalloproteinase (MT1-MMP) regulate fibronectin (FN) assembly by cleaving it, which results in promotion of cell motility and proliferation. FN matrix assembly requires the increased cytoskeletal tension generated by cadherin adhesions. In a co-culture of Rat1 fibroblasts and MT1-MMP-silenced but not control HT1080 cells, FN fibrils extended from Rat1 to cell-matrix adhesions in HT1080 cells, and N-cadherin adhesions were formed between these cells. MT1-MMP knockdown promoted FN matrix assembly and N-cadherin adhesions in HT1080 cells, which was abrogated by double knockdown with either integrin beta1 or FN. Conversely, inhibition of N-cadherin adhesions suppressed FN matrix formation in MT1-MMP-silenced cells. These data demonstrate that FN assembly initiated by MT1-MMP knockdown results in increased N-cadherin adhesions, which are prerequisite for further FN matrix formation.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:23590356, 研究期間(年度):2011–2013", "subitem_description_type": "Other"}, {"subitem_description": "出典:研究課題「細胞外マトリックス分解と細胞運動の極性形成維持機構」課題番号23590356\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学がん進展制御研究所", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00034506", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_17": {"attribute_name": "公開者", "attribute_value_mlt": [{"subitem_publisher": "金沢大学がん進展制御研究所"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=40322119"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=40322119", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590356/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590356/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "滝野, 隆久"}], "nameIdentifiers": [{"nameIdentifier": "124", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40322119", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40322119"}, {"nameIdentifier": "40322119", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40322119"}, {"nameIdentifier": "40322119", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040322119"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-TAKINO-T-kaken 2014-5p.pdf", "filesize": [{"value": "353.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 353400.0, "url": {"label": "CA-PR-TAKINO-T-kaken 2014-5p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/34519/files/CA-PR-TAKINO-T-kaken 2014-5p.pdf"}, "version_id": "684286dc-ce28-48e5-8a26-a06950f6971c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "細胞運動", "subitem_subject_scheme": "Other"}, {"subitem_subject": "浸潤", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ECM", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MMP", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "細胞外マトリックス分解と細胞運動の極性形成維持機構", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "細胞外マトリックス分解と細胞運動の極性形成維持機構"}, {"subitem_title": "A molecular mechanism that regulates extracellular matrix degration and cell polarity in migrating cells", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "3", "path": ["2820"], "permalink_uri": "https://doi.org/10.24517/00034506", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "34519", "relation": {}, "relation_version_is_last": true, "title": ["細胞外マトリックス分解と細胞運動の極性形成維持機構"], "weko_shared_id": 3}
細胞外マトリックス分解と細胞運動の極性形成維持機構
https://doi.org/10.24517/00034506
https://doi.org/10.24517/000345061ab42ffc-27cb-4da0-9a65-eff2435b0310
名前 / ファイル | ライセンス | アクション |
---|---|---|
CA-PR-TAKINO-T-kaken 2014-5p.pdf (353.4 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 細胞外マトリックス分解と細胞運動の極性形成維持機構 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A molecular mechanism that regulates extracellular matrix degration and cell polarity in migrating cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034506 | |||||
ID登録タイプ | JaLC | |||||
著者 |
滝野, 隆久
× 滝野, 隆久 |
|||||
著者別表示 |
Takino, Takahisa
× Takino, Takahisa |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2013 Fiscal Year Final Research Report 巻 2011-2013, p. 5p., 発行日 2014-05-29 |
|||||
出版者 | ||||||
出版者 | 金沢大学がん進展制御研究所 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | MT1-MMPを発現抑制したHT1080細胞とRat1線維芽細胞の共培養では、FN繊維がRat1からHT1080細胞の細胞接着斑に伸展し、N-カドヘリン接着が形成された。また、N-カドヘリン阻害は、MT1-MMPを発現抑制したHT1080細胞におけるFN matrix形成を抑制した。以上の結果から、MT1-MMPは細胞接着斑上における初期のFNの重合を抑制することによりN-カドヘリン接着の安定化とFN matrix形成を阻害し、結果的に腫瘍細胞の細胞運動と増殖を誘導することが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have shown that membrane-type 1 matrix metalloproteinase (MT1-MMP) regulate fibronectin (FN) assembly by cleaving it, which results in promotion of cell motility and proliferation. FN matrix assembly requires the increased cytoskeletal tension generated by cadherin adhesions. In a co-culture of Rat1 fibroblasts and MT1-MMP-silenced but not control HT1080 cells, FN fibrils extended from Rat1 to cell-matrix adhesions in HT1080 cells, and N-cadherin adhesions were formed between these cells. MT1-MMP knockdown promoted FN matrix assembly and N-cadherin adhesions in HT1080 cells, which was abrogated by double knockdown with either integrin beta1 or FN. Conversely, inhibition of N-cadherin adhesions suppressed FN matrix formation in MT1-MMP-silenced cells. These data demonstrate that FN assembly initiated by MT1-MMP knockdown results in increased N-cadherin adhesions, which are prerequisite for further FN matrix formation. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:23590356, 研究期間(年度):2011–2013 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「細胞外マトリックス分解と細胞運動の極性形成維持機構」課題番号23590356 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/)を加工して作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40322119 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40322119 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590356/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590356/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590356/23590356seika/ |