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核内受容体・NF-κBクロストークを標的とした去勢抵抗性前立腺癌に対する治療戦略
https://doi.org/10.24517/00034514
https://doi.org/10.24517/000345147e4c0e2a-0b97-4fc3-b6fd-6ec36536e3a0
名前 / ファイル | ライセンス | アクション |
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HO-PR-KONAKA-H-kaken 2014-5p.pdf (220.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 核内受容体・NF-κBクロストークを標的とした去勢抵抗性前立腺癌に対する治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A novel treatment strategy for castration-refractory prostate cancer targeting cross-talk between NFκB and an intranuclear steroid receptor superfamily | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034514 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小中, 弘之
× 小中, 弘之 |
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著者別表示 |
Konaka, Hiroyuki
× Konaka, Hiroyuki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院 | |||||
書誌情報 |
平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2013 Fiscal Year Final Research Report 巻 2011-2013, p. 5p., 発行日 2014-05-20 |
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出版者 | ||||||
出版者 | 金沢大学附属病院 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 去勢抵抗性前立腺癌に対する新規治療法の確立には,再燃メカニズムの包括的解明は必要不可欠である.核内ステロイド受容体スーパーファミリーに属する,アンドロゲン受容体,グルココルチコイド受容体,エストロゲン受容体の転写系と転写因子NF-κBのシグナル伝達系のクロストークという新たな観点から前立腺癌再燃メカニズムを解明した.また,そのクロストークを標的とした各種シグナル伝達阻害技術を駆使して,去勢抵抗性前立腺癌に対する集学的治療戦略を構築した.さらに,各核内受容体間における転写系シグナル伝達ネットワークの存在が明らかにされ,同クロストークはCRPCに対する新規標的治療となりうる可能性が示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Elucidating a comprehensive mechanism through which most patients with advanced prostate cancer have an initial response to androgen deprivation therapy, but eventually progress to a castration-resistant state is critical to establish a novel treatment strategy for castration refractory prostate cancer (CRPC). We investigate the mechanism of CRPC from the perspective of some cross-talks in signal transduction pathway between NF-kB and an intranuclear steroid receptor superfamily containing androgen receptor, glucocorticoid receptor, and estrogen receptor. Also we target the cross-talk with various methods of inhibiting the signaling transduction pathway and established the integrated treatment strategy of CRPC. Consequently, our study made it clear that cross-talk between NF-kB and an intranuclear steroid receptor superfamily might existence, and also suggested inhibiting the cross-talk of signaling pathway network might be novel therapeutics for the management of CRPC. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:23592328, 研究期間(年度):2011–2013 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「核内受容体・NF-κBクロストークを標的とした去勢抵抗性前立腺癌に対する治療戦略」課題番号23592328 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592328/23592328seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40334768 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40334768 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592328/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592328/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592328/23592328seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592328/23592328seika/ |