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環境ストレス・免疫応答における視床下部・脾臓交感神経系の機能的連関
https://doi.org/10.24517/00034825
https://doi.org/10.24517/000348253f9e2364-9b18-4251-bd4a-f8e780cc1ac1
名前 / ファイル | ライセンス | アクション |
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OC-PR-SHIMIZU-N-kanen 2001-16p.pdf (833.7 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 環境ストレス・免疫応答における視床下部・脾臓交感神経系の機能的連関 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Functional correlations between hypothalamus and splenic sympathetic nervous system under environmental stress and immune response | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034825 | |||||
ID登録タイプ | JaLC | |||||
著者 |
清水, 宣明
× 清水, 宣明 |
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著者別表示 |
Shimizu, Nobuaki
× Shimizu, Nobuaki |
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書誌情報 |
平成12(2000)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2000 Fiscal Year Final Research Report 巻 1998-2000, p. 16p., 発行日 2001-03-01 |
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出版者 | ||||||
出版者 | 金沢大学工学部 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 情動や各種ホメオスタシス系を司る視床下部機能を神経生理学及び神経薬理学的研究から解析した。 (1)拘束ストレスによる摂食抑制とセロトニン系の賦活 拘束ストレス後の摂食抑制はセロトニン受容体阻害剤の前投与で有意に阻害でき、またセロトニン1A受容体のアゴニストである8-OH-DPAT前投与によっても有意に阻害できた。また拘束ストレスによって視床下部セロトニン放出が有意に増加するが、これも8-OH-DPATの前投与で阻害される。これらの結果は、拘束ストレスによってひきおこされる摂食抑制は、背側縫線核から視床下部へ至るセロトニン神経系の賦活に起因すると考えられる。 (2)拘束ストレス時の前頭前野ノルアドレナリン(NA)の動態 前頭前野において拘束ストレス時のNAの動態を解析した。その結果、拘束ストレスによって前頭前野NAの遊離は有意に増大し、これは背側NA束活動の亢進に起因する事が判明した。また拘束ストレスによるNAの遊離はCRF受容体の拮抗薬であるα-herical CRFおよびジアゼパムの拮抗薬であるflumazenilの前投与で有意に拮抗される。以上の結果は、拘束ストレスをはじめとする生体警告情報は前頭前野のNA系を賦活し、これらは脳内benzodiazepine系およびCRF系の活動によって修飾されている可能性を示唆する。 (3)拘束ストレスと脾臓交感神経終末からのNA遊離 拘束ストレスによっておこる脾臓のナチュラルキラー細胞活性の低下が、脾臓交感神経の活動亢進によることを明らかにした。この結果は脳・免疫連関における脾臓交感神経系の重要性を示唆する。さらにCRFの脳室内投与によって脾臓NAの有意な増加が認められ、IL-1βの腹腔内投与による脾臓NA増加がCRF受容体拮抗薬であるα-herical CRFの脳室内投与により拮抗される実験結果もストレス応答における脳・免疫連関の重要性を示唆する。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Various kinds of stressful stimuli stimulate central sympathetic outflow to peripheral nerve endings, and the autonomic nervous system is thought to serve as a major communication link between the brain and the immune system. The purpose of this research project was to study the possible mechanisms of the hypothalamic function in modulating the peripheral immune system, and verify the direct linkage between the activity of the splenic sympathetic nerve and the cytotoxicity of NK cells in the spleen. To further clarify the functional roles of transmitter substances on the behavioral abnormalities caused by the emotional stress, the effects of immobilization stress on food intake were also investigated. 1) Significant reduction of daily food intake was observed after 2 hr immobilization and injection of methysergide antagonized the immobilization-induced anorexia for 3 hr. Brain microdialysis clarified the immobilization induced serotonin release in the hypothalamus. Injection of 8-OH-DPA T itself had no effect on basal release of serotonin, while it significantly blocked the immobilization induced serotonin release in the lateral hypothalamus and stress induced anorexia These results suggest that immobilization-induced anorexia is mediated at least in part through serotonergic mechanisms in the hypothalamus. 2) In vivo microdialysis technique was adopted for chronic monitoring of splenic noradrenaline (NA) release in rats. Immobilization stress caused a rapid increase in the NA release release to about 800% of basal release in conjunction with suppression of NK cell activity in the spleen. Surgical denervation of the splenic sympathetic nerve significantly attenuated the elevated level of NA and also inhibited the immobilization-induced suppressive effect on NK activity. Intracerebroventricular injection of corticotropin releasing factor (2 μg/rat) or intraperitoneal injection of interleukin 1-β ( 50 ng/kg), which suppress the NK activity, significantly increased the splenic NA release. These results suggest that NA has an important role in the control of neuroimmunomodulation in the spleen. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:10470015, 研究期間(年度):1998–2000 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「環境ストレス・免疫応答における視床下部・脾臓交感神経系の機能的連関」研究成果報告書 課題番号10470015 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) 本文データは著者版報告書より作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50019634 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470015/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-10470015/104700152000kenkyu_seika_hokoku_gaiyo/ |