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Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
https://doi.org/10.24517/00049541
https://doi.org/10.24517/00049541e5965f58-cfa5-4940-808e-84a20b62695f
名前 / ファイル | ライセンス | アクション |
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HO-PR-KOMETAN-M-5307523.pdf (903.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-22 | |||||
タイトル | ||||||
タイトル | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049541 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Oka, Rie
× Oka, Rie× Shibata, Kyoko× Sakurai, Masaru× Kometani, Mitsuhiro× Yamagishi, Masakazu× Yoshimura, Kenichi× Yoneda, Takashi |
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著者別表示 |
大家, 理恵
× 大家, 理恵× 柴田, 恭子× 櫻井, 勝× 米谷, 充弘× 山岸, 正和× 吉村, 健一× 米田, 隆 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院研修医・専門医総合教育センター | |||||
書誌情報 |
Journal of Diabetes Research 巻 2017, p. 5307523, 発行日 2017-09-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2314-6745 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2017/5307523 | |||||
出版者 | ||||||
出版者 | Hindawi Limited | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. © 2017 Rie Oka et al. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
権利 | ||||||
権利情報 | Copyright © 2017 Rie Oka et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |