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Expression of 16 kDa proteolipid of vacuolar-tgpe H+-ATPase in human pancreatic cancer
https://doi.org/10.24517/00049833
https://doi.org/10.24517/000498334d13f05c-55e2-4fd8-badd-4c87a9dc4400
名前 / ファイル | ライセンス | アクション |
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ME-PR-ISEKI-S-1511.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-25 | |||||
タイトル | ||||||
タイトル | Expression of 16 kDa proteolipid of vacuolar-tgpe H+-ATPase in human pancreatic cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049833 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ohta, Tetsuo
× Ohta, Tetsuo× Numata, Masayuki× Yagishita, H.× Futagami, Fumio× Tsukioka, Yuhji× Kitagawa, Hirohisa× Kayahara, Masato× Nagakawa, Takukazu× Miyazaki, Itsuo× Yamamoto, Miyuki× Iseki, Shoichi |
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著者別表示 |
太田, 哲生
× 太田, 哲生× 沼田, 雅行× 北川, 裕久× 萱原, 正都× 永川, 宅和× 宮崎, 逸夫× 山本, 美由紀× 井関, 尚一 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
British Journal of Cancer 巻 73, 号 12, p. 1511-1517, 発行日 1996 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0007-0920 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00574355 | |||||
出版者 | ||||||
出版者 | Cancer Research UK | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studies have shown that bafilomycin A1-sensitive vacuolar-type H+-ATPase (V-ATPase) plays important roles in cell growth and differentiation. However, there is no published study that has focused on the expression of V-ATPase in human tumour tissues. This study was designed to examine the mRNA and protein levels for the 16 kilodalton (kDa) proteolipid of V-ATPase in human pancreatic carcinoma tissues. We first investigated the mRNA level for V-ATPase in six cases of invasive pancreatic cancers and two normal pancreases, using reverse transcription-polymerase chain reaction technique. Then, we examined immunohistochemically the level of V-ATPase protein in 49 pancreatic cancers and ten benign cystic neoplasms of the pancreas, using antisera raised against the 16 kDa proteolipid. There was a notable difference in the level of V-ATPase mRNA between normal and pancreatic carcinoma tissues, with no evident difference in the expression of the β-actin gene. Immunohistochemically, 42 out of 46 invasive ductal cancers (92%) displayed a mild to marked immunoreactivity for V-ATPase in the cytoplasm, whereas neither non-invasive ductal cancers nor benign cystic neoplasms expressed detectable immunoreactive proteins. These findings suggest that the overexpression of V-ATPase protein is characteristic of invasive pancreatic tumours. V-ATPase may play some crucial roles in tumour progression. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
権利 | ||||||
権利情報 | Copyright © 1996 Stockton Press. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |