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Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line
https://doi.org/10.24517/00049836
https://doi.org/10.24517/000498364eadbcef-114f-4e95-92b2-1f867a4cca92
名前 / ファイル | ライセンス | アクション |
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ME-PR-ISEKI-S-919.pdf (672.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-25 | |||||
タイトル | ||||||
タイトル | Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049836 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Watanabe, Toshifumi
× Watanabe, Toshifumi× Tajima, Hidehiro× Hayashi, Hironori× Nakagawara, Hisatoshi× Ohnishi, Ichiro× Takamura, Hiroyuki× Ninomiya, Itasu× Kitagawa, Hirohisa× Fushida, Sachio× Tani, Takashi× Fujimura, Takashi× Ohta, Tetsuo× Wakayama, Tomohiko× Iseki, Shoichi× Harada, Shinichi |
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著者別表示 |
田島, 秀浩
× 田島, 秀浩× 林, 泰寛× 中川原, 寿俊× 高村, 博之× 二宮, 致× 北川, 裕久× 伏田, 幸夫× 谷, 卓× 藤村, 隆× 太田, 哲生× 若山, 友彦× 井関, 尚一× 原田, 真市 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
International Journal of Molecular Medicine 巻 28, 号 6, p. 919-925, 発行日 2011-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1107-3756 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11445762 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ijmm.2011.768 | |||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Histone acetylation and deacetylation have been thought to be related to gene expression, and there are many reports indicating that histone deacetylase inhibitors (HDACis) exert antifibrogenic effects in several organs. In injured livers, hepatic stellate cells (HSCs) are activated in response to profibrogenic mediators and produce large amounts of extracellular matrix. In particular, transforming growth factor-β1 (TGF-β1) is considered as a key factor in accelerating hepatic fibrosis because it is released from activated HSCs and further stimulates them. The present study aimed to clarify whether sodium valproate (VPA) has suppressive effects on cultured human HSCs (LI90). We showed that treatment with VPA had no significantly suppressive effect on cell proliferation at a concentration of 1 mM, which corresponded approximately to the serum concentration obtained by the administration of a clinical dose. However, VPA prevented the morphological changes characteristic for activation and inhibited the expression of collagen type 1 α1 (COL1A1) and TGF-β1 in activated LI90 cells at the mRNA and protein levels. Our results support the hypothesis that VPA exerts antifibrogenic activity with little cytotoxicity at 1 mM, and HDACis are expected to be used in clinical practice for the treatment of fibrotic diseases. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 6 months | |||||
権利 | ||||||
権利情報 | Copyright © Spandidos Publications | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |