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Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells
https://doi.org/10.24517/00050263
https://doi.org/10.24517/000502631d5fe7e2-4d40-4e71-bbb0-9d5b7179cf7a
名前 / ファイル | ライセンス | アクション |
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ME-PR-YAMAGISHI-M-522.pdf (159.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-01 | |||||
タイトル | ||||||
タイトル | Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050263 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Sakamoto, Aiji
× Sakamoto, Aiji× Sugamoto, Yuka× Tokunaga, Y.× Yoshimuta, Tsuyoshi× Hayashi, Kenshi× Konno, Tetsuo× Kawashiri, Masa-aki× Takeda, Yoshiyu× Yamagishi, Masakazu |
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著者別表示 |
林, 研至
× 林, 研至× 今野, 哲雄× 川尻, 剛照× 武田, 仁勇× 山岸, 正和 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Journal of International Medical Research 巻 39, 号 2, p. 522-527, 発行日 2011 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0300-0605 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00700686 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1177/147323001103900220 | |||||
出版者 | ||||||
出版者 | SAGE Publications | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ephrin B1 and its cognate receptor, Eph receptor B2, key regulators of embryogenesis, are expressed in human atherosclerotic plaque and inhibit adult human monocyte chemotaxis. Few data exist, however, regarding the gene expression profiles of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells. Gene expression profiles were determined of all 21 members of this gene family in atherosclerosis-related cells by reverse transcription-polymerase chain reaction analysis. The following 17 members were detected in adult human peripheral blood monocytes: EFNA1 and EFNA3 - EFNA5 (coding for ephrins A1 and A3 - A5); EPHA1, EPHA2, EPHA4 - EPHA6 and EPHA8 (coding for Eph receptors A1, A2, A4 - A6 and A8); EFNB1 and EFNB2 (coding for ephrins B1 and B2); and EPHB1 - EPHB4 and EPHB6 (coding for Eph receptors B1 - B4 and B6). THP-1 monocytic cells, Jurkat T cells and adult arterial endothelial cells also expressed multiple EFN and EPH genes. These results indicate that a wide variety of ephrins and Eph receptors might affect monocyte chemotaxis, contributing to the development of atherosclerosis. Their pathological significance requires further study. © 2011 Field House Publishing LLP. | |||||
権利 | ||||||
権利情報 | Copyright © SAGE Publications | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |