WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "3fbfe145-75b2-466c-a8c2-e0d483d5e0ae"}, "_deposit": {"created_by": 18, "id": "44256", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "44256"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00044256", "sets": ["1134"]}, "author_link": ["74507", "74493", "70238", "74502", "74508", "70274", "22334", "74503", "70236", "74505", "74494", "74506", "74495", "74504", "74509", "70253", "70283", "22954", "74500"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "141", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "3", "bibliographic_titles": [{"bibliographic_title": "Kidney International Reports"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "原, 章規"}], "nameIdentifiers": [{"nameIdentifier": "74502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古市, 賢吾"}], "nameIdentifiers": [{"nameIdentifier": "74503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩田, 恭宜"}], "nameIdentifiers": [{"nameIdentifier": "74504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "坂井, 宣彦"}], "nameIdentifiers": [{"nameIdentifier": "74505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "清水, 美保"}], "nameIdentifiers": [{"nameIdentifier": "74506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "金子, 周一"}], "nameIdentifiers": [{"nameIdentifier": "74507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村, 裕之"}], "nameIdentifiers": [{"nameIdentifier": "74508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "和田, 隆志"}], "nameIdentifiers": [{"nameIdentifier": "74509", "nameIdentifierScheme": "WEKO"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) in type 2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diabetes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Embargo Period 12 months", "subitem_description_type": "Other"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00050598", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ekir.2017.08.017", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.elsevier.com/locate/issn/24680249"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/locate/issn/24680249", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2017 International Society of Nephrology / Elsevier (CC-BY-NC-ND)"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2468-0249", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hara, Akinori"}], "nameIdentifiers": [{"nameIdentifier": "70253", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70507045", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70507045"}]}, {"creatorNames": [{"creatorName": "Furuichi, Kengo"}], "nameIdentifiers": [{"nameIdentifier": "70238", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50432125", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50432125"}]}, {"creatorNames": [{"creatorName": "Koshino, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "74493", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuda, Haruka"}], "nameIdentifiers": [{"nameIdentifier": "74494", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tran, Trang Thi Thu"}], "nameIdentifiers": [{"nameIdentifier": "74495", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwata, Yasunori"}], "nameIdentifiers": [{"nameIdentifier": "70274", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90432137", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90432137"}]}, {"creatorNames": [{"creatorName": "Sakai, Norihiko"}], "nameIdentifiers": [{"nameIdentifier": "70283", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60377421", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60377421"}]}, {"creatorNames": [{"creatorName": "Shimizu, Miho"}], "nameIdentifiers": [{"nameIdentifier": "22334", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10547136", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10547136"}]}, {"creatorNames": [{"creatorName": "Kaneko, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "22954", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60185923"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "74500", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wada, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "70236", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40334784", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40334784"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-01-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-WADA-T-133.pdf", "filesize": [{"value": "284.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 284400.0, "url": {"label": "ME-PR-WADA-T-133.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/44256/files/ME-PR-WADA-T-133.pdf"}, "version_id": "84b3a5ec-a9e6-4eec-8aea-e5190068efd1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "autoantibo", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diesdiabetic nephropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "erythropoietin receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "risk factor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD"}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00050598", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-04-23"}, "publish_date": "2018-04-23", "publish_status": "0", "recid": "44256", "relation": {}, "relation_version_is_last": true, "title": ["Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD"], "weko_shared_id": -1}
Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD
https://doi.org/10.24517/00050598
https://doi.org/10.24517/000505982f1cad1d-1648-41cd-9e22-114e5c95d58e
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-WADA-T-133.pdf (284.4 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-04-23 | |||||
タイトル | ||||||
タイトル | Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050598 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Hara, Akinori
× Hara, Akinori× Furuichi, Kengo× Koshino, Akihiko× Yasuda, Haruka× Tran, Trang Thi Thu× Iwata, Yasunori× Sakai, Norihiko× Shimizu, Miho× Kaneko, Shuichi× Nakamura, Hiroyuki× Wada, Takashi |
|||||
著者別表示 |
原, 章規
× 原, 章規× 古市, 賢吾× 岩田, 恭宜× 坂井, 宣彦× 清水, 美保× 金子, 周一× 中村, 裕之× 和田, 隆志 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Kidney International Reports 巻 3, 号 1, p. 133-141, 発行日 2018-01-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2468-0249 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ekir.2017.08.017 | |||||
出版者 | ||||||
出版者 | Elsevier Inc | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) in type 2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diabetes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
権利 | ||||||
権利情報 | Copyright © 2017 International Society of Nephrology / Elsevier (CC-BY-NC-ND) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/24680249 | |||||
関連名称 | http://www.elsevier.com/locate/issn/24680249 |