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心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築
https://doi.org/10.24517/00050735
https://doi.org/10.24517/000507350a235f86-e2d7-4ecd-a917-9e47ebaa56bf
名前 / ファイル | ライセンス | アクション |
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ME-PR-WADA-T-kaken 2011-6p.pdf (206.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-05-14 | |||||
タイトル | ||||||
タイトル | 心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Possible involvement of CD45+/collagen I+ dual positive cells in renal fibrosis and cardiorenal syndrome | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050735 | |||||
ID登録タイプ | JaLC | |||||
著者 |
和田, 隆志
× 和田, 隆志 |
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著者別表示 |
Wada, Takashi
× Wada, Takashi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 6p., 発行日 2011-04-25 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CD45/I型コラーゲン二重陽性細胞に着目し、腎間質線維化ならびに心線維化を中心とした心腎連関への関与を検討した。この線維化を基盤とする心腎連関モデルの作成により、CD45/I型コラーゲン二重陽性細胞の心ならびに腎の線維化への関与が示唆された。また、臨床的に線維化を反映する臨床検査診断法の確立への期待は強い。今回、CD45/I型コラーゲン二重陽性細胞の測定系が樹立され、今後、臨床上の有用性を検討していきたい。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CD45^<+/>Collagen I^+ dual positive cells migrate into fibrotic kidney dependent on chemokine system, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating renal fibrosis. In addition, our present data suggest the possible involvement of CD45^+/Collagen I^+ dual positive cells in cardiac fibrosis, closely related to renal lesions. Furthermore, the detection of CD45^+/Collagen I^+ dual positive cells in circulation has been established in this study. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築」課題番号20590952 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=40334784 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=40334784 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590952/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590952/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/ |