WEKO3
インデックスリンク
アイテム
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サイトカイン産生を誘導する自己抗体を用いた骨髄不全モデルマウスの作成
https://doi.org/10.24517/00050946
https://doi.org/10.24517/000509460a3d418f-eba1-4e0f-8fa5-8a75fa9440dc
名前 / ファイル | ライセンス | アクション |
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ME-PR-TAKAMATSU-H-kaken 2012-4p.pdf (211.2 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-04 | |||||
タイトル | ||||||
タイトル | サイトカイン産生を誘導する自己抗体を用いた骨髄不全モデルマウスの作成 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Generation of bone marrow failure model mice by autoantibodies inducing cytokine production | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050946 | |||||
ID登録タイプ | JaLC | |||||
著者 |
高松, 博幸
× 高松, 博幸 |
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著者別表示 |
Takamatsu, Hiroyuki
× Takamatsu, Hiroyuki |
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書誌情報 |
平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2009-2011, p. 4p., 発行日 2012-05-21 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | モエシンKOマウスは以下の表現型異常が認められた。末梢血白血球減少、貧血、体重減少と脾腫大、骨髄造血幹細胞の減少、骨髄・脾臓のB細胞・形質細胞の減少とT細胞の増加、脾臓の濾胞構造の不明瞭化である。一方、モエシンKOマウスにモエシン蛋白質を免疫したところ、抗モエシン抗体が産生された。前処置後の野生型マウスに抗モエシン抗体を産生する脾臓・骨髄細胞を骨髄内移植したところ、野生型マウスに抗モエシン抗体産生、TNFαとIFNγ濃度の上昇、白血球減少がみとめられたが、血小板減少と貧血は認められなかった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Moesin KO mice grew normally. However, the body weight of moesin KO mice was lower than that of WT mice. Complete blood counts of moesin KO mice revealed leukocytopenia and macrocytic anemia ; platelet counts were comparable. Moesin KO mouse spleens were heavier than those of WT mice and follicle formation in spleens of moesin KO mice were obscure with increased CD3^+lymphocytes and reduced CD19^+lymphocytes as compared with WT mice. BM of moesin KO mice was normocellular and characterized by increased CD3^+lymphocytes and reduced CD19^+lymphocytes as seen in spleens of moesin KO mice. The number of lineage negative, Sca-1^+, and c-Kit^+(LSK) mouse HSCs in moesin KO BM tended to be lower than that of WT mice. Moesin KO spleen/BM cells capable of producing anti-moesin antibodies were infused into BM of WT B6 male mice. Transplanted mice showed leukocytopenia and increase of TNFαand IFNγin plasma compared to WT B6 male mice transplanted with WT spleen/BM cells, but anemia and thrombocytopenia were not observed. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:21591237, 研究期間(年度):2009-2011 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「サイトカイン産生を誘導する自己抗体を用いた骨髄不全モデルマウスの作成」課題番号21591237 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591237/21591237seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=70401932 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=70401932 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591237/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591237/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591237/21591237seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591237/21591237seika/ |