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マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略
https://doi.org/10.24517/00050995
https://doi.org/10.24517/000509952a9ee389-b59a-4c66-8dc7-2274c2f2e15b
名前 / ファイル | ライセンス | アクション |
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ME-PR-SATO-Y-kaken 2018-4p.pdf (416.6 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-04-15 | |||||
タイトル | ||||||
タイトル | マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Novel therapeutic approaches for biliary cystogenesis of Caroli's disease with congenital hepatic fibrosis based on the analysis of microRNAs | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050995 | |||||
ID登録タイプ | JaLC | |||||
著者 |
佐藤, 保則
× 佐藤, 保則 |
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著者別表示 |
Sato, Yasunori
× Sato, Yasunori |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 - 2018-03-31, p. 4p., 発行日 2018-05-25 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | カロリ病+先天性肝線維症の動物モデルであるPCKラットを用いた検討で,PCKラット培養胆管細胞ではmiR-125b-1-3pの発現低下とこれに関連したSmoothenedの発現亢進があり,Hedgehogシグナル伝達系の活性化による胆管細胞の過剰な増殖があることをin vitroで見出した.PCKラットにSmoothendedアンタゴニスト(cyclopamine)を投与することで,肝内胆管の拡張と腎嚢胞の形成をin vivoで有意に抑制することに成功した.以上の結果から,Hedgehogシグナル伝達系の阻害はカロリ病+先天性肝線維症の新たな治療標的となる可能性が示された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The polycystic kidney (PCK) rat was analyzed as an animal model of Caroli’s disease with congenital hepatic fibrosis in this study. In vitro experiments revelated that PCK cholangiocytes were characterized by the reduced expression of miR-125b-1-3p, and the resultant overexpression of Smoothened and the Hedgehog signaling activation led to overgrowth of PCK cholangiocytes. In vivo administration of Smoothened antagonist (cyclopamine) significantly reduced the severity of bile duct dilatation and kidney cyst formation of the PCK rats. These results indicate that inhibition of the Hedgehog signaling represents a potential target of therapy for Caroli’s disease with congenital hepatic fibrosis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K08342, 研究期間(年度):2015-04-01 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「マイクロRNAに着目したカロリ病+先天性肝線維症の新たな治療戦略」課題番号15K08342 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30324073 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30324073 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08342/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08342/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08342/15K08342seika/ |