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食道癌放射線耐性機序解明とHDAC阻害薬による放射線耐性克服の基礎的検討
https://doi.org/10.24517/00051262
https://doi.org/10.24517/00051262d5e0c585-dfa1-4032-8257-a7e5fb792fb0
名前 / ファイル | ライセンス | アクション |
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ME-PR-NINOMIYA-I-kaken 2016-5p.pdf (3.8 MB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-28 | |||||
タイトル | ||||||
タイトル | 食道癌放射線耐性機序解明とHDAC阻害薬による放射線耐性克服の基礎的検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Valproic acid inhibits irradiation-induced epithelial-mesenchymal transition and stem cell-like characteristics in esophageal squamous cell carcinoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051262 | |||||
ID登録タイプ | JaLC | |||||
著者 |
二宮, 致
× 二宮, 致 |
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著者別表示 |
Ninomiya, Itasu
× Ninomiya, Itasu |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院光学医療診療部 | |||||
書誌情報 |
平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2015 Fiscal Year Final Research Report 巻 2013-04-01 - 2016-03-31, p. 5p., 発行日 2016-06-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では、食道癌における放射線耐性のメカニズムを解析し、ヒストン脱アセチル化酵素(HDAC)阻害薬であるValproic acid (VPA)の放射線耐性克服効果を基礎的に検討した。その結果、放射線照射が食道癌細胞の上皮間葉転換(EMT)と癌幹細胞様形質を誘導し、癌細胞の放射線抵抗性や細胞浸潤能や遊走能が亢進した。VPAは放射線照射による食道癌のEMT変化と癌幹細胞様形質の獲得を阻止し放射線性浸潤・遊走能亢進を抑制するとともに、二重鎖切断修復酵素の阻害作用により放射線感受性を増大させ、放射線耐性克服効果を示すことが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the mechanism of radio-resistance and the anti-radioresistant and radiosensitizing effect of classic histone deacetylase (HDAC) inhibitor valproic acid (VPA) in esophageal squamous cell carcinoma (ESCC) cells. First, we showed that 2 Gy of irradiation induced epithelial–mesenchymal transition (EMT) and cancer stem-like cell properties in ESCC TE9 cells. In addition, irradiation enhanced invasion and migration ability with upregulation of matrix metalloproteinases. Second, we found that VPA induced reversal of EMT caused by irradiation in TE9 cells, resulting in attenuated cell invasion and migration abilities. Third, VPA induced Ku70 acetylation and prolonged γH2AX levels after irradiation in three ESCC cell lines (KES, TE9, TE10). Our results suggest that VPA inhibit radiation induced EMT and show radiosensitizing effect by inhibiting DNA double strand break repair pathway in ESCC. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:25461909, 研究期間(年度):2013-04-01 - 2016-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「食道癌放射線耐性機序解明とHDAC阻害薬による放射線耐性克服の基礎的検討」課題番号25461909 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461909/25461909seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=60345618 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=60345618 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461909/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461909/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461909/25461909seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461909/25461909seika/ |