肝胆膵・移植外科領域で頻発する門脈うっ血の影響とその軽減につき，ラットモデルにて研究を行った．門脈うっ血により，小腸粘膜を中心とした障害を受けるが，うっ血による前処置(congestive preconditioning; CPC)を行うことにより，障害は軽減，かつ生存率も有意に改善し，その有用性が示された．また， CPCによる抗アポトーシス経路の誘導が示唆された．
In clinical settings of hepato-pancreato-biliary and liver transplant surgery, portal venous congestion (PVC) is common pathophysiology. Therefore, effect and therapeutic approach for PVC was investigated by rat model. Intestinal mucosa was injured by PVC via apoptosis. By the induction of congestive preconditioning (CPC), intestinal mucosal injury and survival rate were significantly improved. The anti-apoptotic pathways was suspected to be involved in this availability, based on the result from immunohistochemical analysis.
門脈阻血に伴う多臓器うっ血の周術期における影響と多臓器相関
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ME-PR-HAYASHI-H-kaken 2016-4p.pdf
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