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覚醒剤反復前投与による小胞体ストレスと神経障害: 黒質線条体路障害の解明に向けて
https://doi.org/10.24517/00051813
https://doi.org/10.24517/000518138c4a78cf-8096-4c37-a2aa-983c74b8ad16
名前 / ファイル | ライセンス | アクション |
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ME-PR-TAKEICHI T-kaken 2018-4p.pdf (185.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-04-19 | |||||
タイトル | ||||||
タイトル | 覚醒剤反復前投与による小胞体ストレスと神経障害: 黒質線条体路障害の解明に向けて | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis to the nigrostriatal pathway of the low-dose methamphetamine | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051813 | |||||
ID登録タイプ | JaLC | |||||
著者 |
武市, 敏明
× 武市, 敏明 |
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著者別表示 |
Takeichi, Toshiaki
× Takeichi, Toshiaki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 - 2018-03-31, p. 4p., 発行日 2018-05-28 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 少量の覚せい剤を反復投与した動物を濫用初期モデル動物とした。このモデル動物に10 mg/kgの覚せい剤を投与後の中脳および線条体の細胞ストレス、神経細胞および神経活動のマーカー蛋白の変化を解析した。その結果、中脳では、抑制性神経のGABA作動性神経のマーカー(GAD67)の有意な増加を認め、線条体では小胞体ストレスマーカーおよびGAD67だけでなく、興奮性神経のグルタミン酸作動性神経のマーカーと、神経活動の指標となるc-fosの有意な増加を認めた。以上の結果より我々のモデル動物では、黒質線条体路だけでなく線条体視床路にも影響し、線条体の神経細胞の易活性化が惹起されていることが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effects of administering low-dose Methamphetamine (METH) prior to the administration of high-dose METH on the neural activity of rats were examined. The rats were administered a low dose of METH or saline for 5 consecutive days (m5 and s5 groups), followed by a high dose of METH on Day 6 (m5M and s5M groups). Markers of neuronal cells, such as vesicular glutamate transporter 2 (VGLUT) in the striatum and glutamate decarboxylase 67 (GAD67) in the midbrain and striatum, were analyzed by western blotting. The expression of c-fos, a marker of neural activity, in the striatum was analyzed using immunohistochemistry. The expression levels of VGLUT and GAD67 were significantly higher in the m5M than in the s5M group. The numbers of c-fos-positive cells were significantly higher in m5M than in the other groups. These results suggest that preadministration of low-dose METH prior to high-dose METH administration in rats may alter thalamostriatal pathway as well as nigrostriatal pathway. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K08888, 研究期間(年度):2015-04-01 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「覚醒剤反復前投与による小胞体ストレスと神経障害: 黒質線条体路障害の解明に向けて」課題番号15K08888 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08888/15K08888seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=90460360 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=90460360 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08888/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08888/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08888/15K08888seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08888/15K08888seika/ |