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胃癌におけるCCND1, CCNE1及びCDK6 遺伝子増幅の検索
https://doi.org/10.24517/00052868
https://doi.org/10.24517/000528684163083b-a032-46bf-b44c-55144a45a68d
名前 / ファイル | ライセンス | アクション |
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ME-PR-OOI-A-kaken 2019-4p.pdf (88.2 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-04-10 | |||||
タイトル | ||||||
タイトル | 胃癌におけるCCND1, CCNE1及びCDK6 遺伝子増幅の検索 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of gene amplifications of CCND1, CCNE1, and CDK6 in gastric cancers | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00052868 | |||||
ID登録タイプ | JaLC | |||||
著者 |
大井, 章史
× 大井, 章史 |
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著者別表示 |
Ooi, Akishi
× Ooi, Akishi |
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書誌情報 |
平成30(2018)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2018 Fiscal Year Final Research Report 巻 2016-04-01 - 2019-03-31, p. 4p., 発行日 2019-05-21 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 増幅遺伝子はしばしば分子標的の対象となる。本研究では、胃癌及び乳癌において、遺伝子増幅の報告のあるそれぞれ16遺伝子、22遺伝子についてmuliple ligation-dependent probe amplification とfluorescence in situ hybridizationを用いて増幅を検索した。胃癌ではCCNE1, CCND1、CDK4遺伝子とERBB2, EGFR, KRAS遺伝子との同時増幅が高頻度にみられた。また乳癌では8p11-12、11q11.3 と17q12-21上で複数の遺伝子増幅がおこっており、8p11 と 11q13上の遺伝子の同時増幅がみられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In solid cancers amplified genes are potential targets of molecular therapies. In this study the 16 genes and 22 genes reportedly amplified in gastric and mammary cancers were examined by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization. In gastric cancers amplification of G1-S regulatory genes (CCNE1, CCND1and CDK6) were co-amplified with ERBB2, EGFR and/or KRAS in single cancer nuclei. In breast cancers The frequencies of the amplification of four regions containing known driver oncogenes were as follows: 8p11 (ZNF703, FGFR1, ADAM9 and IKBKB), 8q24 (MYC), 11q13 (CCND1, C11ORF30), and 17q11-21 (CPD, MED1, ERBB2, CDC6, TOP2A, MAPT) exhibited amplification in 9.6%, 9.6%, 12.4%, and 12.1% of the tumors, respectively. Co-localization of the amplicon on 8p11 and the amplicon on 11q13 in single cells was frequently observed. Precise and feasible analysis of gene amplification status can be obtained using a combination of MLPA and FISH. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:16K08686, 研究期間(年度):2016-04-01 - 2019-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「胃癌におけるCCND1, CCNE1及びCDK6 遺伝子増幅の検索」研究成果報告書 課題番号16K08686 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08686/16K08686seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50160411 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50160411 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08686/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08686/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08686/16K08686seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08686/16K08686seika/ |