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Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease
https://doi.org/10.24517/00053008
https://doi.org/10.24517/00053008fafccdc0-cd00-4697-957c-1ee40c5643ec
名前 / ファイル | ライセンス | アクション |
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ME-PR-TADA-H-783.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article_04(1) | |||||
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公開日 | 2019-01-10 | |||||
タイトル | ||||||
タイトル | Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053008 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Tada, Hayato
× Tada, Hayato× Nohara, Atsushi× Inazu, Akihiro× Sakuma, Nagahiko× Mabuchi, Hiroshi× Kawashiri, Masa-aki |
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著者別表示 |
多田, 隼人
× 多田, 隼人× 野原, 淳× 稲津, 明広× 馬淵, 宏× 川尻, 剛照 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院循環器内科 | |||||
書誌情報 |
Journal of Atherosclerosis and Thrombosis 巻 25, 号 9, p. 783-789, 発行日 2018 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-3478 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11018976 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5551/jat.RV17024 | |||||
出版者 | ||||||
出版者 | 日本動脈硬化学会 = Japan Atherosclerosis Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sitosterolemia is a rare inherited disease characterized by increased levels of plant sterols, such as sitosterol. The cause of this disease is ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively) gene mutations. Recent advances in genetics have revealed that the prevalence of subjects with deleterious mutations in ABCG5 and/or ABCG8 genes could be more than 1 in ~200,000 individuals among the general population. Furthermore, accumulated evidence, including infantile cases exhibiting progression/regression of systemic xanthomas associated with LDL cholesterol levels, have shown that the elevation of LDL cholesterol seems to be the major cause of development of atherosclerosis and not the elevation of sitosterol. Regarding therapies, LDL apheresis, as well as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, could be useful for sitosterolemia, in addition to ezetimibe and/or colestimide. In this study, we provide the current understanding and future perspectives of sitosterolemia, which is currently considered an extremely rare disorder but is expected to be much more prevalent in clinical settings. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. | |||||
権利 | ||||||
権利情報 | Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.j-athero.org/ | |||||
関連名称 | http://www.j-athero.org/ |