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Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol
https://doi.org/10.24517/00053045
https://doi.org/10.24517/000530458897d114-4bec-4d9a-ab73-58d24076b1f0
名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMADA-T-199.pdf (628.2 kB)
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Item type | 学術雑誌論文 / Journal Article_04(1) | |||||
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公開日 | 2019-01-10 | |||||
タイトル | ||||||
タイトル | Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053045 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Tokuhara, Daisuke
× Tokuhara, Daisuke× Shimada, Tsutomu× Asami, Akitoshi× Takahashi, Akiko× Kobayashi, Hiroko× Saimaru, Hiroshi× Aburada, Masaki |
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著者別表示 |
嶋田, 努
× 嶋田, 努 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
書誌情報 |
Journal of Traditional Medicines 巻 30, 号 5, p. 199-205, 発行日 2013 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-1447 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11339/jtm.30.199 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 = Medical and Pharmaceutical Society for WAKAN-YAKU | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Zingiberis Rhizoma の辛味成分である 6-shogaol およびその代謝物 6-paradol の体内動態および薬理活性について, 検討した。 6-shogaol (10 mg/kg) をラットに経口投与した際の血漿中 6-shogaol および 6-paradol 濃度を LC/MS/MSを用いて測定したところ, ともに投与 5 分後で Cmax に到達し, 投与 2 時間後までに速やかに血漿中から消失した。 代謝物である血漿中 6-paradol 濃度はいずれの採血時間においても, 6-shogaol 濃度に比べて約 4 倍高い値を示した。 次に, 6-shogaol および6-paradolの薬理活性について検討したところ, in vitro 実験において 6-paradol は 6-shogaol に比べ約 6 倍強い COX-2 阻害活性を示し, in vivo 実験においても 6-paradol が 6-shogaol より有意に強い抗炎症作用, 鎮痛作用および解熱作用を示した。 このことから, Zingiberis Rhizoma 中の 6-shogaol は体内で速やかに 6-paradol に代謝されること, また代謝物である 6-paradol が抗炎症作用を示すメイン化合物であることが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study examined the pharmacokinetics and pharmacological activities of 6-shoganol, a pungent ingredient of Zingiberis Rhizoma, and its metabolite, 6-paradol. The concentrations of 6-shogaol and 6-paradol in rat plasma determined by LC/MS/MS reached their maximum values (Cmax) at 5 minutes after oral administration of 6-shogaol (10 mg/kg). Both 6-shogaol and 6-paradol were eliminated from the plasma within 2 hours after injection. The plasma concentration of 6-paradol, the metabolite, was about 4 times higher than that of 6-shogaol at all points during blood sampling. Next, pharmacological activities of 6-shogaol and 6-paradol were studied. In vitro experiment revealed that the cyclooxygenase-2-inhibitory activity of 6-paradol was about 6 times stronger than that of 6-shogaol. In vivo experiments, 6-paradol demonstrated significantly stronger anti-inflammatory, analgesic, and antipyretic activities compared to 6-shogaol. These results suggest that 6-shogaol in Zingiberis Rhizoma is metabolized rapidly to 6-paradol and that 6-paradol is the main compound having anti-inflammatory activity. © 2013, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved. | |||||
権利 | ||||||
権利情報 | © Medical and Pharmaceutical Society for WAKAN-YAKU | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jtm/-char/ja | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/jtm/-char/ja | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.wakan-iyaku.gr.jp/ | |||||
関連名称 | https://www.wakan-iyaku.gr.jp/ |