WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "67e0049d-2a33-4cce-9016-c84aa5c61603"}, "_deposit": {"created_by": 18, "id": "47557", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "47557"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00047557", "sets": ["1134"]}, "author_link": ["84851", "23919", "69497", "2209", "84802", "80335", "23442", "84801", "79940", "84815", "21404", "174", "302", "55", "20747", "70236", "74062", "84803", "76763"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-21", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageStart": "e0197604", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "PLoS ONE"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "安藝, 翔"}], "nameIdentifiers": [{"nameIdentifier": "84851", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80767210", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80767210"}]}, {"creatorNames": [{"creatorName": "吉岡, 和晃"}], "nameIdentifiers": [{"nameIdentifier": "174", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80333368", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80333368"}, {"nameIdentifier": "80333368", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80333368"}, {"nameIdentifier": "80333368", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080333368"}]}, {"creatorNames": [{"creatorName": "多久和, 典子"}], "nameIdentifiers": [{"nameIdentifier": "84815", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70150290", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70150290"}]}, {"creatorNames": [{"creatorName": "和田, 隆志"}], "nameIdentifiers": [{"nameIdentifier": "74062", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40334784", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40334784"}]}, {"creatorNames": [{"creatorName": "髙橋, 智聡"}], "nameIdentifiers": [{"nameIdentifier": "69497", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50283619", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50283619"}]}, {"creatorNames": [{"creatorName": "西内, 巧"}], "nameIdentifiers": [{"nameIdentifier": "302", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20334790", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20334790"}, {"nameIdentifier": "20334790", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20334790"}, {"nameIdentifier": "20334790", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020334790"}]}, {"creatorNames": [{"creatorName": "多久和, 陽"}], "nameIdentifiers": [{"nameIdentifier": "55", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60171592", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60171592"}, {"nameIdentifier": "60171592", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60171592"}, {"nameIdentifier": "60171592", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060171592"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Idiopathic pulmonary fibrosis is a devastating disease with poor prognosis. The pathogenic role of the lysophospholipid mediator sphingosine-1-phosphate and its receptor S1PR2 in lung fibrosis is unknown. We show here that genetic deletion of S1pr2 strikingly attenuated lung fibrosis induced by repeated injections of bleomycin in mice. We observed by using S1pr2 LacZ/+ mice that S1PR2 was expressed in alveolar macrophages, vascular endothelial cells and alveolar epithelial cells in the lung and that S1PR2-expressing cells accumulated in the fibrotic legions. Bone marrow chimera experiments suggested that S1PR2 in bone marrow–derived cells contributes to the development of lung fibrosis. Depletion of macrophages greatly attenuated lung fibrosis. Bleomycin administration stimulated the mRNA expression of the profibrotic cytokines IL-13 and IL-4 and the M2 markers including arginase 1, Fizz1/Retnla, Ccl17 and Ccl24 in cells collected from broncho-alveolar lavage fluids (BALF), and S1pr2 deletion markedly diminished the stimulated expression of these genes. BALF cells from bleomycin–administered wild-type mice showed a marked increase in phosphorylation of STAT6, a transcription factor which is activated downstream of IL-13, compared with saline–administered wild-type mice. Interestingly, in bleomycin–adminis-tered S1pr2 -/- mice, STAT6 phosphorylation in BALF cells was substantially diminished compared with wild-type mice. Finally, pharmacological S1PR2 blockade in S1pr2 +/+ mice alleviated bleomycin–induced lung fibrosis. Thus, S1PR2 facilitates lung fibrosis through the mechanisms involving augmentation of IL-13 expression and its signaling in BALF cells, and represents a novel target for treating lung fibrosis. © 2018 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00053881", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1371/journal.pone.0197604", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197604"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197604", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "copyright © 2018, The Author(s) / Public Library of Science"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhao, Juanjuan"}], "nameIdentifiers": [{"nameIdentifier": "84801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto, Yasuo"}], "nameIdentifiers": [{"nameIdentifier": "84802", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80293877", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80293877"}]}, {"creatorNames": [{"creatorName": "Asano, Yuya"}], "nameIdentifiers": [{"nameIdentifier": "84803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishimaru, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "80335", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70595446", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70595446"}]}, {"creatorNames": [{"creatorName": "Aki, Sho"}], "nameIdentifiers": [{"nameIdentifier": "23442", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80767210", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80767210"}]}, {"creatorNames": [{"creatorName": "Yoshioka, Kazuaki"}], "nameIdentifiers": [{"nameIdentifier": "76763", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80333368", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80333368"}]}, {"creatorNames": [{"creatorName": "Takuwa, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "21404", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70150290", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70150290"}, {"nameIdentifier": "70150290", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070150290"}]}, {"creatorNames": [{"creatorName": "Wada, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "70236", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40334784", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40334784"}]}, {"creatorNames": [{"creatorName": "Inagaki, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "20747", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Chiaki"}], "nameIdentifiers": [{"nameIdentifier": "2209", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50283619", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50283619"}]}, {"creatorNames": [{"creatorName": "Nishiuchi, Takumi"}], "nameIdentifiers": [{"nameIdentifier": "79940", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20334790", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20334790"}]}, {"creatorNames": [{"creatorName": "Takuwa, Yoh"}], "nameIdentifiers": [{"nameIdentifier": "23919", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60171592", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60171592"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-TAKUWA-Y-0197604.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "ME-PR-TAKUWA-Y-0197604.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/47557/files/ME-PR-TAKUWA-Y-0197604.pdf"}, "version_id": "52f0b264-7139-460b-bb5f-f9e8b4bc887e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages."}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00053881", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-15"}, "publish_date": "2019-04-15", "publish_status": "0", "recid": "47557", "relation": {}, "relation_version_is_last": true, "title": ["Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages."], "weko_shared_id": -1}
Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.
https://doi.org/10.24517/00053881
https://doi.org/10.24517/000538814cc83919-1159-422c-a3c2-8bdba745f6b4
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-TAKUWA-Y-0197604.pdf (1.1 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-04-15 | |||||
タイトル | ||||||
タイトル | Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053881 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Zhao, Juanjuan
× Zhao, Juanjuan× Okamoto, Yasuo× Asano, Yuya× Ishimaru, Kazuhiro× Aki, Sho× Yoshioka, Kazuaki× Takuwa, Noriko× Wada, Takashi× Inagaki, Yutaka× Takahashi, Chiaki× Nishiuchi, Takumi× Takuwa, Yoh |
|||||
著者別表示 |
安藝, 翔
× 安藝, 翔× 吉岡, 和晃× 多久和, 典子× 和田, 隆志× 髙橋, 智聡× 西内, 巧× 多久和, 陽 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
PLoS ONE 巻 13, 号 5, p. e0197604, 発行日 2018-05-21 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0197604 | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Idiopathic pulmonary fibrosis is a devastating disease with poor prognosis. The pathogenic role of the lysophospholipid mediator sphingosine-1-phosphate and its receptor S1PR2 in lung fibrosis is unknown. We show here that genetic deletion of S1pr2 strikingly attenuated lung fibrosis induced by repeated injections of bleomycin in mice. We observed by using S1pr2 LacZ/+ mice that S1PR2 was expressed in alveolar macrophages, vascular endothelial cells and alveolar epithelial cells in the lung and that S1PR2-expressing cells accumulated in the fibrotic legions. Bone marrow chimera experiments suggested that S1PR2 in bone marrow–derived cells contributes to the development of lung fibrosis. Depletion of macrophages greatly attenuated lung fibrosis. Bleomycin administration stimulated the mRNA expression of the profibrotic cytokines IL-13 and IL-4 and the M2 markers including arginase 1, Fizz1/Retnla, Ccl17 and Ccl24 in cells collected from broncho-alveolar lavage fluids (BALF), and S1pr2 deletion markedly diminished the stimulated expression of these genes. BALF cells from bleomycin–administered wild-type mice showed a marked increase in phosphorylation of STAT6, a transcription factor which is activated downstream of IL-13, compared with saline–administered wild-type mice. Interestingly, in bleomycin–adminis-tered S1pr2 -/- mice, STAT6 phosphorylation in BALF cells was substantially diminished compared with wild-type mice. Finally, pharmacological S1PR2 blockade in S1pr2 +/+ mice alleviated bleomycin–induced lung fibrosis. Thus, S1PR2 facilitates lung fibrosis through the mechanisms involving augmentation of IL-13 expression and its signaling in BALF cells, and represents a novel target for treating lung fibrosis. © 2018 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
権利 | ||||||
権利情報 | copyright © 2018, The Author(s) / Public Library of Science | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197604 | |||||
関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197604 |