We aimed to clarify molecular mechanisms how growth factors regulate self-renewing activity of tissue type specific stem cells by using novel bioinfomatics. As a result, we identified Hes1 as a key molecular target of self-renewal of neural stem cells and FRS2alpha-Shp2-Tbx2 pathway as a key pathway for development of cardiac progenitor cells. Moreover, we identified NFkB as a key molecular target for self-renewing mammalian stem cells as well as breast cancer stem cells.
増殖因子による幹細胞並びに個体発生の動態制御のシステム生物学的解析
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CA-PR-GOTO-N-kaken 2011-8p.pdf
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