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ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築
https://doi.org/10.24517/00057098
https://doi.org/10.24517/0005709826d8a51a-0a11-49a5-ae61-d50c5e996a8e
名前 / ファイル | ライセンス | アクション |
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ME-PR-KAWAI-K-kaken 2012-5p.pdf (269.8 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-02-20 | |||||
タイトル | ||||||
タイトル | ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The probe design strategy of post-FDG tumor diagnostic agents based on the functional biomolecule expression analysis of human cultured cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00057098 | |||||
ID登録タイプ | JaLC | |||||
著者 |
川井, 惠一
× 川井, 惠一 |
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著者別表示 |
Kawai, Keiichi
× Kawai, Keiichi |
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書誌情報 |
平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2009-2011, p. 5p., 発行日 2012-05-15 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域保健学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では、薬剤評価に用いるヒト培養細胞の遺伝子発現レベルをデータベース化し、癌細胞に高発現している機能性分子を予め探索するとともに、特にポストFDG製剤の中でも有力候補であるアミノ酸製剤を取り上げ、腫瘍で特異的に高発現が認められるアミノ酸トランスポータに高親和性を示す標識アミノ酸の集積機序を詳細に検討し、アミノ酸トランスポータ遺伝子発現と腫瘍集積性との相関からその設計戦略の妥当性を評価した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | While searching this research for the functional biomolecule used by the database for the gene expression level of the human cultured cells for evaluation of imaging probes, and it has high-expressed to the tumor cell beforehand, the amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:21659286, 研究期間(年度):2009-2011 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築」課題番号21659286 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30204663 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30204663 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659286/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659286/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/ |