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糖尿病における心・腎線維化機序に関わる新規骨髄由来細胞の同定と解析
https://doi.org/10.24517/00058820
https://doi.org/10.24517/000588202cf29aa2-a73f-4ce6-a5cd-ee2dee29a9da
名前 / ファイル | ライセンス | アクション |
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HO-PR-SAGARA-A-kaken 2017-4p.pdf (268.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-07-30 | |||||
タイトル | ||||||
タイトル | 糖尿病における心・腎線維化機序に関わる新規骨髄由来細胞の同定と解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of new myeloid-derived fibrosis-inducing cells accounting for cardiorenal connection in diabetic nephropathy | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00058820 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Sagara, Akihiro
× Sagara, Akihiro |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2015-04-01 – 2017-03-31, p. 4p., 発行日 2017-05-23 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 全身GFP発現マウスの骨髄を野生型B6マウスに移植し,一側尿管結紮(UUO)を行うことで腎線維化モデルを作成した.心,腎に浸潤したGFP+CD45+Sca1+細胞に着目し,Fibroblastsとの共培養やCOL-GFPマウスを用いた骨髄移植による検討にて,CD45+Sca1+細胞の線維化誘導能とコラーゲン産生能を確認した.また CD45+Sca1+細胞よりRNAを抽出し,Genechipによる遺伝子発現解析を行った.共培養とフローサイトメトリーによる検証を経て,CD45+Sca1+細胞の中に更なる亜集団が存在することを示した.この細胞群はヒト末梢血にも存在し,腎機能の増悪に伴って増加した. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To chase and identify fibrosis-related cell types, we used unilateral ureteral obstruction model mice, which showed renal and heart fibrosis, in combination with GFP-based tracing systems such as bone-marrow transplantation (BMT). We found BM-derived mononuclear cell cluster of CD45+Sca1+ cells mobilized and accumulated in the fibrotic lesions of kidney and heart using flow cytometry (FCM). The CD45+Sca1+ cells had an activating potential for collagen production of cultured fibroblasts and also produced type 1 collagen by themselves. Genechip analyses and FCM revealed the subpopulation of CD45+Sca1+ cells, which were related to chemotaxis and innate immunity. These cells were also detected in human peripheral blood and increased in proportion to kidney dysfunction. In this study, we succeeded to identify a new myeloid-derived fibrosis-inducing cells, which could provide a new avenue in fibrosis. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K19449, 研究期間(年度):2015-04-01 – 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「糖尿病における心・腎線維化機序に関わる新規骨髄由来細胞の同定と解析」研究成果報告書 課題番号15K19449 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19449/15K19449seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=00707060 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=00707060 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K19449/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K19449/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19449/15K19449seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K19449/15K19449seika/ |