動物は環境から種々の感覚情報を受け取り、適切な行動を選択する。本研究ではショウジョウバエをモデルとして、脳で複数の感覚入力を受ける神経群aSP2(雄の性行動時に活動する神経として本研究者らが報告)に着目し、感覚情報の統合と行動決定を行う神経機構の一端を明らかにすることを目指した。aSP2神経の活動を抑制したショウジョウバエの雄では求愛が断続的になったことから、aSP2神経は求愛持続の決断や性行動のモチベーション維持に関わることを見出した。また、雌との接触によって雄の脳内でaSP2神経の活動が変動することを明らかにした。
Animals continuosly make decisions based on sensory information they receive from the environment. In the current study, I aimed to investigate the neural basis of this decision-making process by using sexual behavior of the fruit fly Drosophila melanogaster as a model. Here I focused on a cluster of neurons termed aSP2 (which we previously reported as a cluster activated when males exhibit courtship), located in the higher order brain region of males, which receives multimodal sensory information. aSP2-silenced males were not able to sustain courtship towards a female, suggesting that aSP2 is involved in the decision-making process of whether or not to continue courting, and/or the regulation of courtship vigor. In addition, I found that the activity level of aSP2 neurons changes when a male touches a female by his front leg.