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上皮性がん幹細胞と白血病幹細胞の共通制御メカニズムへのアプローチ
https://doi.org/10.24517/00059388
https://doi.org/10.24517/000593882e201fea-3dee-4a2f-931b-d6b9b338d16b
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKA-K-kaken 2016-6p.pdf (309.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-11-02 | |||||
タイトル | ||||||
タイトル | 上皮性がん幹細胞と白血病幹細胞の共通制御メカニズムへのアプローチ | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Common molecular mechanisms regulating murine breast cancer stem cells and leukemia stem cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00059388 | |||||
ID登録タイプ | JaLC | |||||
著者 |
仲, 一仁
× 仲, 一仁 |
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著者別表示 |
Naka, Kazuhito
× Naka, Kazuhito |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 広島大学 / 金沢大学がん進展制御研究所 | |||||
書誌情報 |
平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2015 Fiscal Year Final Research Report 巻 2014-04-01 – 2016-03-31, p. 6p., 発行日 2016-05-25 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | がん幹細胞はがんの再発や転移を引き起こす原因となる細胞として注目されているが,上皮性腫瘍におけるがん幹細胞の維持機構は明らかでない.本研究では,がん幹細胞の制御メカニズムの共通性を手掛りとして上皮性腫瘍のがん幹細胞の特性を明らかにするため,CML幹細胞と乳がん幹細胞の代謝産物の比較解析を行った.その結果,乳がん幹細胞, 並びにCML幹細胞において,不飽和脂肪酸ドコサヘキソン酸が発現上昇していることを見出した.当該研究成果によって,不飽和脂肪酸の獲得や蓄積,あるいはその代謝産物が乳がん幹細胞やCML幹細胞の共通の制御メカニズムに関与している可能性が示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although it is now widely accepted that cancer stem cells are the cell-of-origin of the vast majority of mature cancer cells and are reportedly responsible for the recurrence of disease following anti-cancer therapy, the molecular mechanisms regulating cancer stem cells in epithelial tumors has remained elusive. The biological characteristics of mature cancer cells appear to be distinct among breast cancer cells originate from endoderm and leukemia cells originate from mesoderm. However, I hypothesized that common molecular mechanisms such as stem cell quiescence and/or therapeutic resistance might sustain the long-term survival of breast cancer stem cells and chronic myelogenous leukemia (CML) stem cells. In this study, I used sophisticated metabolomics techniques to investigate the distinct and common molecular mechanisms maintaining self-renewal capacity of murine breast cancer stem cells and murine CML stem cells in vivo. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26670135, 研究期間(年度):2014-04-01 – 2016-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「上皮性がん幹細胞と白血病幹細胞の共通制御メカニズムへのアプローチ」課題番号26670135 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26670135/26670135seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=70372688 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=70372688 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26670135/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26670135/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26670135/26670135seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26670135/26670135seika/ |