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自閉症スペクトラム障害幼児における遺伝子多型、脳内ネットワークと表現型の関係
https://doi.org/10.24517/00059432
https://doi.org/10.24517/0005943284f8c933-a30f-4a20-aeea-a81a0a0e7e52
名前 / ファイル | ライセンス | アクション |
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CH-PR-KIKUCHI-M-kaken 2017-5p.pdf (239.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-11-05 | |||||
タイトル | ||||||
タイトル | 自閉症スペクトラム障害幼児における遺伝子多型、脳内ネットワークと表現型の関係 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00059432 | |||||
ID登録タイプ | JaLC | |||||
著者 |
菊知, 充
× 菊知, 充 |
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著者別表示 |
Kikuchi, Mitsuru
× Kikuchi, Mitsuru |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学子どものこころの発達研究センター | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2014-04-01 – 2017-03-31, p. 5p., 発行日 2017-06-17 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ASDの症状を、行動評価と、MEGをもちいた生理学的指標を用いて、より客観的に数値化し、自閉症のリスク型の遺伝子多型とどのように関連するかを調べた。ASD幼児(延べN=71)および定型発達幼児(延べN=102)が参加した。現時点でMET遺伝子のrs1858830の一塩基多型については、ASD幼児33名、定型発達(TD)幼児で30名の解析が終了した。結果、ASD群はTD群と比較してリスク型の遺伝子多型Cを含む群は、作動記憶の発達に遅れが認められた。社会性については、同様の傾向が認められたが有意差にはいならなかった。MEGをもちいたAEFの潜時についてはTD群がよりリスク遺伝子の影響を受けていた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The symptom of ASD was evaluated using the behavioral and neurophysiological methods. We researched the effect of the genotype (which was thought to be risk type for ASD) on phenotype measured by behavioral data and end-phenotype measured by MEG. Young children with ASD (N=71: including the repeated subjects) and typically developing children (N=102: including the repeated subjects) participated. At the present moment, single nucleotide polymorphism of rs1858830 in a MET gene have identified in 33 children with ASD and 30 TD children. We defined CC and a CG genotype (which include risk type genetic polymorphism C) as CC_CG group, and we compared some phenotype and end-phenotype between CC_CG and GG groups. As the result, in the ASD group including genetic polymorphism C, developmental delay was observed in working memory task. On the other hand, TD group was affected by the risk gene more about the latency of auditory evoked field measured by MEG. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26293262, 研究期間(年度):2014-04-01 – 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「自閉症スペクトラム障害幼児における遺伝子多型、脳内ネットワークと表現型の関係」研究成果報告書 課題番号26293262 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26293262/26293262seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=00377384 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=00377384 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26293262/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26293262/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26293262/26293262seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26293262/26293262seika/ |