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Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132
https://doi.org/10.24517/00062684
https://doi.org/10.24517/00062684be065b0a-5d7b-4d56-8f52-adb843a22b38
名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-773.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-06-28 | |||||
タイトル | ||||||
タイトル | Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062684 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Matsumoto, Yoko
× Matsumoto, Yoko× Miyamoto, Yuichiro× Cabral, Horacio× Matsumoto, Yu× Nagasaka, Kazunori× Nakagawa, Shunsuke× Yano, Tetsu× Maeda, Daichi× Oda, Katsutoshi× Kawana, Kei× Nishiyama, Nobuhiro× Kataoka, Kazunori× Fujii, Tomoyuki |
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著者別表示 |
前田, 大地
× 前田, 大地 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Cancer Science 巻 107, 号 6, p. 773-781, 発行日 2016-06-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-9032 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-7006 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11808050 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/cas.12926 | |||||
出版者 | ||||||
出版者 | Japanese Cancer Association 日本癌学会 / Wiley Open Access | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Treatment of recurrent or advanced cervical cancer is still limited, and new therapeutic choices are needed for improving prognosis and quality of life of patients. Because human papilloma virus (HPV) infection is critical in cervical carcinogenesis, with the E6 and E7 oncogenes of HPV degrading tumor suppressor proteins through the ubiquitin proteasome system, the inhibition of the ubiquitin proteasome system appears to be an ideal target to suppress the growth of cervical tumors. Herein, we focused on the ubiquitin proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) as an anticancer agent against cervical cancer cells, and physically incorporated it into micellar nanomedicines for achieving selective delivery to solid tumors and improving its in vivo efficacy. These MG132-loaded polymeric micelles (MG132/m) showed strong tumor inhibitory in vivo effect against HPV-positive tumors from HeLa and CaSki cells, and even in HPV-negative tumors from C33A cells. Repeated injection of MG132/m showed no significant toxicity to mice under analysis by weight change or histopathology. Moreover, the tumors treated with MG132/m showed higher levels of tumor suppressing proteins, hScrib and p53, as well as apoptotic degree, than tumors treated with free MG132. This enhanced efficacy of MG132/m was attributed to their prolonged circulation in the bloodstream, which allowed their gradual extravasation and penetration within the tumor tissue, as determined by intravital microscopy. These results support the use of MG132 incorporated into polymeric micelles as a safe and effective therapeutic strategy against cervical tumors. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | |||||
権利 | ||||||
権利情報 | Copyright © Japanese Cancer Association 日本癌学会 / Wiley Open Access | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006/ | |||||
関連名称 | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/10.1111/cas.12926 | |||||
関連名称 | https://onlinelibrary.wiley.com/doi/10.1111/cas.12926 |