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An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array
https://doi.org/10.24517/00062689
https://doi.org/10.24517/00062689034d6388-403b-4248-9cb6-6d5ffcb9e00c
名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-209.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-06-28 | |||||
タイトル | ||||||
タイトル | An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062689 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Tamura, Daisuke
× Tamura, Daisuke× Maeda, Daichi× Sato, Toshiharu× Sugawara, Tae× Shirasawa, Hiromitsu× Shimizu, Dai× Sato, Naoki× Goto, Akiteru× Terada, Yukihiro |
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著者別表示 |
前田, 大地
× 前田, 大地 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Genes Chromosomes and Cancer 巻 59, 号 3, p. 209-213, 発行日 2019-07-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1045-2257 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1098-2264 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11620217 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/gcc.22817 | |||||
出版者 | ||||||
出版者 | Wiley | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An extragonadal yolk sac tumor (YST) is a rare malignant germ cell tumor that usually occurs in childhood. The pathogenesis of extragonadal YST remains largely unknown, especially with regards to its cell of origin. Herein, we report a case of extragonadal YST arising in the uterine round ligament. A 31-year-old Japanese woman, para 2, underwent partial resection of a left-sided, 5-cm, solid inguinal mass. Intraoperative findings showed enlargement of the uterine round ligament in the inguinal canal. Pathological evaluation diagnosed the mass as YST with a mature teratoma (MT) component. The preoperative α-fetoprotein level was markedly elevated, at 24 790 ng/mL. Postoperative magnetic resonance imaging revealed a right ovarian MT and a 3-cm mass remaining in the left lower abdominal wall. The patient underwent total abdominal hysterectomy, bilateral adnexectomy, and left inguinal mass resection. We sampled three frozen tissues (YST, right ovarian MT, and left normal ovary) and performed a single nucleotide polymorphism (SNP) array. Pathological evaluation revealed remnant extragonadal YST in the left inguinal region. The SNP array demonstrated a completely homozygous YST genotype. Copy number variations were gains of 1p, 1q, 2p, 3p, 7p, 8p, 10q, 14q, 18p, 20q, Xp, and Xq and losses of 12q, 20p, and Xq. The right ovarian MT and left normal ovary were partially homozygous and heterozygous, respectively. The evidence suggests that this neoplasm is presumed to be a postmeiotic germ cell origin. © 2019 Wiley Periodicals, Inc. | |||||
権利 | ||||||
権利情報 | Copyright © 2019 Wiley Periodicals, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2264 | |||||
関連名称 | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2264 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1002/gcc.22817 | |||||
関連名称 | https://onlinelibrary.wiley.com/doi/full/10.1002/gcc.22817 |