WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "bc03f952-93df-4f85-8b8d-754c0b510e6d"}, "_deposit": {"created_by": 18, "id": "56420", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "56420"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00056420", "sets": ["1134"]}, "author_link": ["98884", "98880", "98890", "98605", "98881", "97904", "98554", "98607", "98892", "98893", "25170", "20164", "98599", "98604", "98885", "98594", "98615", "98606", "98891", "98895", "98601", "98888", "98598", "98400", "98596", "98889", "98612", "98882", "98597", "98886", "98887", "98608", "98883", "98609", "98611", "98613", "98602", "98879", "98894", "98595", "98610", "47997", "98603", "98616", "98614", "98600"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-08-09", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "12451", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Nature Research"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "前田, 大地"}], "nameIdentifiers": [{"nameIdentifier": "97904", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30585500", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30585500"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10 \u002717, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10 \u00279, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00062694", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/ncomms12451", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.nature.com/ncomms/index.html"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/ncomms/index.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://www.nature.com/articles/ncomms12451"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/ncomms12451", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © Nature Research / Nature Publishing Group"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12645905", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shiraishi, Kouya"}], "nameIdentifiers": [{"nameIdentifier": "98594", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Yukinori"}], "nameIdentifiers": [{"nameIdentifier": "98595", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "98596", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamatani, Yoichiro"}], "nameIdentifiers": [{"nameIdentifier": "98597", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Momozawa, Yukihide"}], "nameIdentifiers": [{"nameIdentifier": "98598", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ashikawa, Kyota"}], "nameIdentifiers": [{"nameIdentifier": "98599", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunitoh, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "98600", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "98601", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takano, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "98602", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Kimihiro"}], "nameIdentifiers": [{"nameIdentifier": "98603", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Akiteru"}], "nameIdentifiers": [{"nameIdentifier": "98604", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuta, Koji"}], "nameIdentifiers": [{"nameIdentifier": "98605", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Shun-ichi"}], "nameIdentifiers": [{"nameIdentifier": "98606", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohe, Yuichiro"}], "nameIdentifiers": [{"nameIdentifier": "98607", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "98608", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "98609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nokihara, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "98610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furuta, Koh"}], "nameIdentifiers": [{"nameIdentifier": "98611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "98612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "98613", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hishida, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "98614", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuboi, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "98615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuchihara, Katsuya"}], "nameIdentifiers": [{"nameIdentifier": "98616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyagi, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "98879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Kazumi"}], "nameIdentifiers": [{"nameIdentifier": "98880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Haruhiko"}], "nameIdentifiers": [{"nameIdentifier": "98881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokose, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "98882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagashima, Toshiteru"}], "nameIdentifiers": [{"nameIdentifier": "98883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohtaki, Yoichi"}], "nameIdentifiers": [{"nameIdentifier": "98884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Daichi"}], "nameIdentifiers": [{"nameIdentifier": "97904", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30585500", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30585500"}]}, {"creatorNames": [{"creatorName": "Imai, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "98885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamiya, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "98554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, Hiromi"}], "nameIdentifiers": [{"nameIdentifier": "98886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Akira"}], "nameIdentifiers": [{"nameIdentifier": "98887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "98888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sunami, Kuniko"}], "nameIdentifiers": [{"nameIdentifier": "98889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Motonobu"}], "nameIdentifiers": [{"nameIdentifier": "98400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inazawa, Johji"}], "nameIdentifiers": [{"nameIdentifier": "20164", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "98890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Teruhiko"}], "nameIdentifiers": [{"nameIdentifier": "25170", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokota, Jun"}], "nameIdentifiers": [{"nameIdentifier": "98891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, Fumihiko"}], "nameIdentifiers": [{"nameIdentifier": "98892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Keitaro"}], "nameIdentifiers": [{"nameIdentifier": "98893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Daigo, Yataro"}], "nameIdentifiers": [{"nameIdentifier": "98894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo, Michiaki"}], "nameIdentifiers": [{"nameIdentifier": "98895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "47997", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-06-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-MAEDA-D-12451.pdf", "filesize": [{"value": "542.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 542000.0, "url": {"label": "ME-PR-MAEDA-D-12451.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/56420/files/ME-PR-MAEDA-D-12451.pdf"}, "version_id": "36ef4785-ea99-4eab-9dea-52fb17e524fb"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma"}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00062694", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-06-28"}, "publish_date": "2021-06-28", "publish_status": "0", "recid": "56420", "relation": {}, "relation_version_is_last": true, "title": ["Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma"], "weko_shared_id": -1}
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma
https://doi.org/10.24517/00062694
https://doi.org/10.24517/0006269414b4a29f-4b11-4645-9ede-115762afdc38
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-MAEDA-D-12451.pdf (542.0 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-06-28 | |||||
タイトル | ||||||
タイトル | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062694 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Shiraishi, Kouya
× Shiraishi, Kouya× Okada, Yukinori× Takahashi, Atsushi× Kamatani, Yoichiro× Momozawa, Yukihide× Ashikawa, Kyota× Kunitoh, Hideo× Matsumoto, Shingo× Takano, Atsushi× Shimizu, Kimihiro× Goto, Akiteru× Tsuta, Koji× Watanabe, Shun-ichi× Ohe, Yuichiro× Watanabe, Yukio× Goto, Yasushi× Nokihara, Hiroshi× Furuta, Koh× Yoshida, Akihiko× Goto, Koichi× Hishida, Tomoyuki× Tsuboi, Masahiro× Tsuchihara, Katsuya× Miyagi, Yohei× Tanaka, Kazumi× Nakayama, Haruhiko× Yokose, Tomoyuki× Nagashima, Toshiteru× Ohtaki, Yoichi× Maeda, Daichi× Imai, Kazuhiro× Minamiya, Yoshihiro× Sakamoto, Hiromi× Saito, Akira× Shimada, Yoko× Sunami, Kuniko× Saito, Motonobu× Inazawa, Johji× Nakamura, Yusuke× Yoshida, Teruhiko× Yokota, Jun× Matsuda, Fumihiko× Matsuo, Keitaro× Daigo, Yataro× Kubo, Michiaki× Kohno, Takashi |
|||||
著者別表示 |
前田, 大地
× 前田, 大地 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Nature Research 巻 7, p. 12451, 発行日 2016-08-09 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12645905 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/ncomms12451 | |||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10 '17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10 '9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. | |||||
権利 | ||||||
権利情報 | Copyright © Nature Research / Nature Publishing Group | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/ncomms/index.html | |||||
関連名称 | http://www.nature.com/ncomms/index.html | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/ncomms12451 | |||||
関連名称 | https://www.nature.com/articles/ncomms12451 |