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シグマ-1受容体標的放射性プローブの開発
https://doi.org/10.24517/00065229
https://doi.org/10.24517/0006522943a41ad7-4c0d-4d69-a638-02c8633edded
名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-66_403.pdf (897.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-01-28 | |||||
タイトル | ||||||
タイトル | シグマ-1受容体標的放射性プローブの開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of radiolabeled probes directed against sigma-1 receptors | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00065229 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小川, 数馬
× 小川, 数馬× 増田, 涼平× 柴, 和弘 |
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著者別表示 |
Ogawa, Kazuma
× Ogawa, Kazuma× Masuda, Ryohei× Shiba, Kazuhiro |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学疾患モデル総合研究センター | |||||
書誌情報 |
分析化学 en : Bunseki Kagaku 巻 66, 号 6, p. 403-411, 発行日 2017 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0525-1931 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00222633 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2116/bunsekikagaku.66.403 | |||||
出版者 | ||||||
出版者 | Japan Society for Analytical Chemistry 日本分析化学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It has been reported that sigma-1 receptors regulate the release of signaling substances in the central nervous systems and are related to various diseases, such as schizophrenia, stress disorders, dementia, amyotrophic lateral sclerosis (ALS), and cancer. If the quantification of the sigma-1 receptors is possible, the pathophysiology, the stage, and the early detection of the diseases could be understandable. Molecular imaging using Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) and radioactive probes makes noninvasive quantification of the in vivo metabolism and function possible. Currently, only nuclear medicine diagnosis using PET or SPECT can quantify the sigma-1 receptors. Therefore, there is great expectation for the development of molecular probes to image the sigma-1 receptors specifically. In this paper, we introduce our research on the development of radiohalogen-labeled molecular probes directed against the sigma-1 receptors. © 2017 The Japan Society for Analytical Chemistry. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | シグマ-1受容体は中枢や末梢しょう神経系において情報伝達物質放出の調節に関係していることが判明しており,統合失調症,ストレス性疾患,認知症,筋萎縮性側索硬化症(ALS),癌がんなど多くの疾患との関係も報告されている.したがって,シグマ-1受容体を定量化できれば,種々の疾患の病態生理,進行度(重症度)の把握,早期診断が可能と成り得ると共に治療指針決定のための情報が得られる可能性がある.放射性プローブを投与し,そのプローブから放出される放射線を専用のカメラで画像化する,いわゆる,ポジトロン断層撮影(Positron Emission Tomography, PET)や単一光子放射断層撮影(Single Photon Emission Computed Tomography, SPECT)を用いた分子イメージング(核医学診断)により,非侵襲的に生体内の代謝や機能を定量可能であり,現在,PETやSPECTを用いる核医学診断的手法のみがシグマ-1受容体を定量可能である.そのため,シグマ-1受容体を特異的に画像化する分子プローブの開発の期待は大きい.本稿では,著者らが進めてきたシグマ-1受容体を標的とした放射性ハロゲン標識分子プローブの開発についての研究成果を紹介する. | |||||
権利 | ||||||
権利情報 | Copyright © Japan Society for Analytical Chemistry 日本分析化学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/bunsekikagaku/-char/ja/ | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/bunsekikagaku/-char/ja/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jsac.jp/ | |||||
関連名称 | https://www.jsac.jp/ |