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Development of novel radiogallium-labeled bone imaging agents using oligo-aspartic acid peptides as carriers
https://doi.org/10.24517/00065240
https://doi.org/10.24517/00065240c579b006-bf74-4e35-beb2-be70d3b5e361
名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-8-e84335.pdf (540.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-01-31 | |||||
タイトル | ||||||
タイトル | Development of novel radiogallium-labeled bone imaging agents using oligo-aspartic acid peptides as carriers | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00065240 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Ishizaki, Atsushi× Takai, Kenichiro× Kitamura, Yoji× Kiwada, Tatsuto× Shiba, Kazuhiro× Odani, Akira |
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著者別表示 |
小川, 数馬
× 小川, 数馬× 北村, 暘二× 柴, 和弘× 小谷, 明 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学疾患モデル総合研究センター | |||||
書誌情報 |
PLoS ONE 巻 8, 号 12, p. e84335, 発行日 2013-12-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0084335 | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 68Ga (T1/2 = 68 min, a generator-produced nuclide) has great potential as a radionuclide for clinical positron emission tomography (PET). Because poly-glutamic and poly-aspartic acids have high affinity for hydroxyapatite, to develop new bone targeting 68Ga-labeled bone imaging agents for PET, we used 1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA) as a chelating site and conjugated aspartic acid peptides of varying lengths. Subsequently, we compared Ga complexes, Ga-DOTA-(Asp)n (n = 2, 5, 8, 11, or 14) with easy-to-handle 67Ga, with the previously described 67Ga-DOTA complex conjugated bisphosphonate, 67Ga-DOTA-Bn-SCN-HBP. After synthesizing DOTA-(Asp)n by a Fmoc-based solid-phase method, complexes were formed with 67Ga, resulting in 67Ga-DOTA-(Asp)n with a radiochemical purity of over 95% after HPLC purification. In hydroxyapatite binding assays, the binding rate of 67Ga-DOTA-(Asp)n increased with the increase in the length of the conjugated aspartate peptide. Moreover, in biodistribution experiments, 67Ga-DOTA-(Asp) 8, 67Ga-DOTA-(Asp)11, and 67Ga-DOTA- (Asp)14 showed high accumulation in bone (10.5±1.5, 15.1±2.6, and 12.8±1.7% ID/g, respectively) but were barely observed in other tissues at 60 min after injection. Although bone accumulation of 67Ga-DOTA-(Asp)n was lower than that of 67Ga-DOTA-Bn-SCN-HBP, blood clearance of 67Ga-DOTA-(Asp)n was more rapid. Accordingly, the bone/blood ratios of 67Ga-DOTA-(Asp) 11 and 67Ga-DOTA-(Asp)14 were comparable with those of 67Ga-DOTA-Bn-SCN-HBP. In conclusion, these data provide useful insights into the drug design of 68Ga-PET tracers for the diagnosis of bone disorders, such as bone metastases. © 2013 Ogawa et al. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CC-BY 4.0 | |||||
権利 | ||||||
権利情報 | Copyright © 2013 Ogawa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.plosone.org/ | |||||
関連名称 | http://www.plosone.org/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084335 | |||||
関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084335 |