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肝細胞癌の超高危険群および発癌機序の解明
https://doi.org/10.24517/00068308
https://doi.org/10.24517/00068308c1614d32-b97f-485b-9deb-492741a10b3d
名前 / ファイル | ライセンス | アクション |
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ME-PR-HATTORI-N-kaken 1988-2p.pdf (81.8 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2023-01-26 | |||||
タイトル | ||||||
タイトル | 肝細胞癌の超高危険群および発癌機序の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Super high risk group of hepatocellular carcinoma and the elucidation of carcinogenesis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00068308 | |||||
ID登録タイプ | JaLC | |||||
著者 |
服部, 信
× 服部, 信 |
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著者別表示 |
Hattori, Nobu
× Hattori, Nobu |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部 | |||||
書誌情報 |
昭和60(1985)年度 科学研究費補助金 一般研究(A) 研究成果報告書概要 en : 1985 Fiscal Year Final Research Report Summary 巻 1984 – 1985, p. 2p., 発行日 1988-11-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 肝硬変における肝癌合併予知のリスク・スコアを確立した。すなわち肝硬変と診断後少くとも1年以上を経て肝癌合併の明らかとなった75例と肝癌合併を見ずに死亡したか、未だ肝癌合併の明らかではない300例を対象として、性・年令や腹水・血中HBs抗原・アルコール歴など肝硬変と診断時比較的容易に入手しうる10個のリスク・ファクターを取り上げ、コンピューター解析し各々のリスク・スコアを算定、最初にえられた複雑な数値を簡易化、最高10点、最低0点となるように設定した。Retrospectiveな検討の結果6点以上が超高危険群と考えられた。リスク・スコア設定後20例の肝癌合併例と10例の非合併剖検例が集積された。前者の平均リスク・スコアは6.6点で、後者の4.2点より有意に高く、前者の9例が根治切除された。従がって本リスク・スコアは肝硬変における肝癌合併予知とくに根治切除例の早期発見に有用と考えられる。 先に樹立しえたヌードマウス移植ウッドチャック肝細胞癌継代系を利用し、ウッドチャック肝癌培養細胞系を確立、WH257GE10と命名した。本培養細胞系には安定した状態で、WHVDNAが組込まれており、この組込まれたDNAをクローニングしたところ、WHVゲノムの組込みとともにAC-cluster,T-clusterおよびAT-clusterがみられた。これらの組込みが肝発癌と何んらかの関連を有していることが推測された。 ヒト肝細胞癌培養系の1つであるアレキサンダーcell lineについて、成長因子growth factorの1つであるAsialogly coproteinのreceptorの有無を調べた結果、弱いながらもその存在が明らかとなった。またインターフェロンを作用させたところ、明らかに成長抑制作用が認められた。 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Risk score to predict hepatocellular carcinoma (HCC) development in liver cirrhosis (LC) was established according to multivariate computer generated analysis. Retrospectively, a risk score of greater than 6 appeared to place patients in a super high risk group. Prospectively, HCC developed in 20 cases with LC. In all but five cases, the risk factor score was greater than 6 at the time of diagnosis of LC. In 8 of these 20 cases, radical resection of HCC was performed. These results suggest that risk factor score at the time of diagnosis of LC may be useful in predicting the development of HCC in LC, especially surgically-resectable ones. A new cell line derived from a woodchuck HCC serially transplanted in athymic nude mice has been established and named WH257GE10. Woodchuck hepatitis virus DNA is integrated into cellular DNA. The major part of the integrated DNA was cloned and a unique sequence was detected. A sialoglycoprotein, a growth factor, receptor was investigated on a human HCC cell line. The specific uptake of this protein was found. As a preliminary approach to the clinical application of interferon (IFN) on hepatocellular carcinoma, the effect of human IFN- <beta> on the growth of a human HCC cell line, PLC/PRF/5, was studied. The cell growth in vitro was inhibited dosedependently when IFN was given at the concentrations of 30 to 1,000IU/ml. When the effect of IFN was examined on several cloned sublines of PLC/PRF/5 cells, heterogeniety in susceptibility to the growth-inhibitory effect was shown. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号59440040, 研究期間(年度):1984 – 1985 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝細胞癌の超高危険群および発癌機序の解明」課題番号59440040 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-59440040/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30019640 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30019640 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-59440040/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-59440040/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-59440040/594400401985kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-59440040/594400401985kenkyu_seika_hokoku_gaiyo/ |