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Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis
http://hdl.handle.net/2297/14503
http://hdl.handle.net/2297/145030ef01f43-9cb1-43e8-b8a8-a88e4b71cec9
名前 / ファイル | ライセンス | アクション |
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SC-PR-TAKURA-N-267.pdf (525.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Li, Wen-Ling
× Li, Wen-Ling× Yamada, Yoshihiro× Ueno, Masaya× Nishikawa, Satomi× Nishikawa, Shin-Ichi× Takakura, Nobuyuki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学大学院自然科学研究科 | |||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 大阪大学微生物病研究所 情報伝達分野 | |||||
書誌情報 |
Journal of Biochemistry 巻 140, 号 2, p. 267-273, 発行日 2006-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-924X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694073 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jb/mvj151 | |||||
出版者 | ||||||
出版者 | 日本生化学会 = Japanese Biochemical Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The hematopoietic system undergoes a qualitative change during the embryogenesis of most vertebrates. It is designated as the shift of primitive to definitive hematopoiesis and suitable microenvironment must be established to support this shift. While studying the role of platelet derived growth factor receptor α (PDGFR α) in embryonic hematopoiesis, we found that it was expressed in a stromal cell component of liver, a major site of this shift, but not in the yolk sac, the site of primitive hematopoiesis. Thus, we considered that development of PDGFRα positive stromal cells is an essential requirement for this shift. Without PDFGRα positive cell component, erythropoiesis was suppressed in the culture of fetal liver. Moreover, injection of an antagonistic anti-PDGFRα monoclonal antibody during embryogenesis suppressed the production of definitive erythrocytes. These indicated that PDGF exerts its effect on a subset of stromal components to prepare a microenvironment that can support the definitive erythropoiesis. © 2006 The Japanese Biochemical Society. | |||||
権利 | ||||||
権利情報 | © 2006 The Japanese Biochemical Society. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1093/jb/mvj151 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://jb.oxfordjournals.org/cgi/content/abstract/140/2/267 |