WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "5ac0ee36-6aa4-4a79-8ebf-dee0e0be322d"}, "_deposit": {"created_by": 3, "id": "13295", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "13295"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00013295", "sets": ["1134"]}, "author_link": ["21517", "21525", "21518", "21519", "21524", "15392", "21516", "21520", "21521", "21526", "21522", "21523"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-07-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "2481", "bibliographicPageStart": "2471", "bibliographicVolumeNumber": "118", "bibliographic_titles": [{"bibliographic_title": "Journal of Clinical Investigation"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Stress-induced analgesia (SIA) is a key component of the defensive behavioral \"fight-or-flight\" response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin/orexin (Hcrt) and nociceptin/orphanin FQ (N/OFQ) peptidergic systems in the regulation of SIA. Using immunohistochemistry in brain tissue from wild-type mice, we identified N/OFQ-containing fibers forming synaptic contacts with Hcrt neurons at both the light and electron microscopic levels. Patch clamp recordings in GFP-tagged mouse Hcrt neurons revealed that N/OFQ hyperpolarized, decreased input resistance, and blocked the firing of action potentials in Hcrt neurons. N/OFQ postsynaptic effects were consistent with opening of a G protein-regulated inwardly rectifying K+ (GIRK) channel. N/OFQ also modulated presynaptic release of GABA and glutamate onto Hcrt neurons in mouse hypothalamic slices. Orexin/ataxin-3 mice, in which the Hcrt neurons degenerate, did not exhibit SIA, although analgesia was induced by i.c.v. administration of Hcrt-1. N/OFQ blocked SIA in wild-type mice, while coadministration of Hcrt-1 overcame N/OFQ inhibition of SIA. These results establish what is, to our knowledge, a novel interaction between the N/OFQ and Hcrt systems in which the corticotropin-releasing factor and N/OFQ systems coordinately modulate the Hcrt neurons to regulate SIA.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Society for Clinical Investigation"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1172/JC135115", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00695520", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0021-9738", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Xie, Xinmin"}], "nameIdentifiers": [{"nameIdentifier": "21516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wisor, Jonathan P."}], "nameIdentifiers": [{"nameIdentifier": "21517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Junko"}], "nameIdentifiers": [{"nameIdentifier": "21518", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30420079", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030420079"}]}, {"creatorNames": [{"creatorName": "Crowder, Tara L."}], "nameIdentifiers": [{"nameIdentifier": "21519", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "LeWinter, Robin"}], "nameIdentifiers": [{"nameIdentifier": "21520", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Khroyan, Taline V."}], "nameIdentifiers": [{"nameIdentifier": "21521", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamanaka, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "21522", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Diano, Sabrina"}], "nameIdentifiers": [{"nameIdentifier": "21523", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horvath, Takeshi L."}], "nameIdentifiers": [{"nameIdentifier": "21524", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakurai, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "15392", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60251055", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60251055"}, {"nameIdentifier": "60251055", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060251055"}]}, {"creatorNames": [{"creatorName": "Toll, Lawrence"}], "nameIdentifiers": [{"nameIdentifier": "21525", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kilduff, Thomas S."}], "nameIdentifiers": [{"nameIdentifier": "21526", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SAKURAI-T-2417.pdf", "filesize": [{"value": "712.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 712500.0, "url": {"label": "ME-PR-SAKURAI-T-2417.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/13295/files/ME-PR-SAKURAI-T-2417.pdf"}, "version_id": "cc683d13-04db-4998-bc58-da6e6fbd6932"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/11557", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "13295", "relation": {}, "relation_version_is_last": true, "title": ["Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia"], "weko_shared_id": -1}
Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
http://hdl.handle.net/2297/11557
http://hdl.handle.net/2297/1155772fb14a0-5e60-42ca-93a8-0f63a658f7cc
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-SAKURAI-T-2417.pdf (712.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Xie, Xinmin
× Xie, Xinmin× Wisor, Jonathan P.× Hara, Junko× Crowder, Tara L.× LeWinter, Robin× Khroyan, Taline V.× Yamanaka, Akihiro× Diano, Sabrina× Horvath, Takeshi L.× Sakurai, Takeshi× Toll, Lawrence× Kilduff, Thomas S. |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Journal of Clinical Investigation 巻 118, 号 7, p. 2471-2481, 発行日 2008-07-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9738 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1172/JC135115 | |||||
出版者 | ||||||
出版者 | American Society for Clinical Investigation | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Stress-induced analgesia (SIA) is a key component of the defensive behavioral "fight-or-flight" response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin/orexin (Hcrt) and nociceptin/orphanin FQ (N/OFQ) peptidergic systems in the regulation of SIA. Using immunohistochemistry in brain tissue from wild-type mice, we identified N/OFQ-containing fibers forming synaptic contacts with Hcrt neurons at both the light and electron microscopic levels. Patch clamp recordings in GFP-tagged mouse Hcrt neurons revealed that N/OFQ hyperpolarized, decreased input resistance, and blocked the firing of action potentials in Hcrt neurons. N/OFQ postsynaptic effects were consistent with opening of a G protein-regulated inwardly rectifying K+ (GIRK) channel. N/OFQ also modulated presynaptic release of GABA and glutamate onto Hcrt neurons in mouse hypothalamic slices. Orexin/ataxin-3 mice, in which the Hcrt neurons degenerate, did not exhibit SIA, although analgesia was induced by i.c.v. administration of Hcrt-1. N/OFQ blocked SIA in wild-type mice, while coadministration of Hcrt-1 overcame N/OFQ inhibition of SIA. These results establish what is, to our knowledge, a novel interaction between the N/OFQ and Hcrt systems in which the corticotropin-releasing factor and N/OFQ systems coordinately modulate the Hcrt neurons to regulate SIA. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |