WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "d79e7e46-f4c3-41f2-81b5-21666c9b4d39"}, "_deposit": {"created_by": 3, "id": "13375", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "13375"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00013375", "sets": ["1134"]}, "author_link": ["20218"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-10-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "7", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "60", "bibliographic_titles": [{"bibliographic_title": "Journal of Dermatological Science"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "While B cells are generally considered to be positive regulators of humoral immune responses due to their ability to differentiate into plasmablasts/plasma cells and produce antibodies, B cells also modulate immune responses through antigen presentation and cytokine secretion. Moreover, \" regulatory B cells\" that suppress immune responses have been recognized as an important new component of the immune system. In mice, the function of regulatory B cells is almost exclusively dependent on IL-10. The cell-surface phenotype of murine IL-10-producing regulatory B cells is reported to be CD1dhiCD5+ or CD1dhiCD21hiCD23+IgMhi, and thus their phenotype overlaps with that of CD5+ B-1a cells, CD1dhiCD21hiCD23loIgMhi marginal zone (MZ) B cells, and CD1dhiCD21hiCD23hiIgMhi T2-MZ precursor B cells. Contrary to earlier work that suggested a minor role for B cells in contact hypersensitivity, regulatory B cells are now known to have a critical inhibitory functions in this type of immune response. Furthermore, studies using murine disease models have demonstrated that regulatory B cells play a significant role in autoimmune connective tissue diseases such as rheumatoid arthritis and systemic lupus erythematosus, as well as organ-specific autoimmune diseases including experimental autoimmune encephalomyelitis and inflammatory bowel disease. In comparison to mouse regulatory B cells, little is known regarding their human counterparts. One recent study demonstrates that human CD19+CD24hiCD38hi B cells possess regulatory capacity. Clarifying the molecular mechanisms by which regulatory B cells suppress immune responses will be of great benefit in the development of new B cell-targeted therapeutic strategies. © 2010 Japanese Society for Investigative Dermatology.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.jdermsci.2010.08.010", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/locate/issn/09231811", "subitem_relation_type_select": "URI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1075636X", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0923-1811", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujimoto, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "20218", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90272591", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090272591"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-FUJIMOTO-M-1.pdf", "filesize": [{"value": "331.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 331100.0, "url": {"label": "ME-PR-FUJIMOTO-M-1.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/13375/files/ME-PR-FUJIMOTO-M-1.pdf"}, "version_id": "f710d45b-13c0-4dd2-a542-95cce7485bb3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "B10 cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Contact hypersensitivity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-10", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Regulatory B cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Systemic lupus erythematosus", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Regulatory B cells in skin and connective tissue diseases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Regulatory B cells in skin and connective tissue diseases"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/25437", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "13375", "relation": {}, "relation_version_is_last": true, "title": ["Regulatory B cells in skin and connective tissue diseases"], "weko_shared_id": -1}
Regulatory B cells in skin and connective tissue diseases
http://hdl.handle.net/2297/25437
http://hdl.handle.net/2297/254372d6791da-a532-4928-b594-d686dbffbc75
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-FUJIMOTO-M-1.pdf (331.1 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Regulatory B cells in skin and connective tissue diseases | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fujimoto, Manabu
× Fujimoto, Manabu |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Journal of Dermatological Science 巻 60, 号 1, p. 1-7, 発行日 2010-10-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0923-1811 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1075636X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jdermsci.2010.08.010 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | While B cells are generally considered to be positive regulators of humoral immune responses due to their ability to differentiate into plasmablasts/plasma cells and produce antibodies, B cells also modulate immune responses through antigen presentation and cytokine secretion. Moreover, " regulatory B cells" that suppress immune responses have been recognized as an important new component of the immune system. In mice, the function of regulatory B cells is almost exclusively dependent on IL-10. The cell-surface phenotype of murine IL-10-producing regulatory B cells is reported to be CD1dhiCD5+ or CD1dhiCD21hiCD23+IgMhi, and thus their phenotype overlaps with that of CD5+ B-1a cells, CD1dhiCD21hiCD23loIgMhi marginal zone (MZ) B cells, and CD1dhiCD21hiCD23hiIgMhi T2-MZ precursor B cells. Contrary to earlier work that suggested a minor role for B cells in contact hypersensitivity, regulatory B cells are now known to have a critical inhibitory functions in this type of immune response. Furthermore, studies using murine disease models have demonstrated that regulatory B cells play a significant role in autoimmune connective tissue diseases such as rheumatoid arthritis and systemic lupus erythematosus, as well as organ-specific autoimmune diseases including experimental autoimmune encephalomyelitis and inflammatory bowel disease. In comparison to mouse regulatory B cells, little is known regarding their human counterparts. One recent study demonstrates that human CD19+CD24hiCD38hi B cells possess regulatory capacity. Clarifying the molecular mechanisms by which regulatory B cells suppress immune responses will be of great benefit in the development of new B cell-targeted therapeutic strategies. © 2010 Japanese Society for Investigative Dermatology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/09231811 |